Cellular autonomy of hyperactivity in segmental X chromosomal aneuploids of Drosophila and dosage compensation
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Results support the transcriptional constancy of the entire X chromosome, as proposed by Maroni and Lucchesi, and cellular autonomy of hyperactivity of the single X chromosome even at the level of segments of the X is evident.Abstract:
Transcription in 9A–11A aneuploid mosaic female larvae of Drosophila melanogaster has been assessed autoradiographically. Eleven larvae were found to exhibit mosaicism out of sixty-six larvae scanned and the percentage of XO and XX nuclei varied from approximately 9 to 100. Irrespective of the number of XX nuclei present the XO nuclei (duplicated for 9A–11A) invariably showed hyperactivity for both the segments. The XX nucleus exhibited a dosage effect for all the three segments of 9A–11A. Results support the transcriptional constancy of the entire X chromosome, as proposed by Maroni and Lucchesi. Cellular autonomy of hyperactivity of the single X chromosome even at the level of segments of the X is thus evident from the present results.read more
Citations
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Journal ArticleDOI
A different level of X-chromosomal transcription in an in (1) BM2 (reinverted) strain and in its hyperploid derivatives resolves an X-coded regulatory activity for dosage compensation in Drosophila
A. S. Mukherjee,Mita Ghosh +1 more
TL;DR: The results suggest that there may be a modulator gene complex (M + ) in the 16A7-B2 region as well as regulators elsewhere on the X , which in combination influence the hyperactivity of the male X in Drosophila.
Journal ArticleDOI
Transcriptive and replicative activity of the x chromosome in an autosomal segmental hyperploid in drosophila and its significance
Syamasri Ghosh,Avinaba Mukherjee +1 more
TL;DR: The findings lead us to suggest that the signals emanating from autosome(s) do not interfere with the primary modulation inherent in the X chromosome, but act on a modulated organization of the same at a second step evoking higher activity in the male X chromosome.
Book ChapterDOI
Dosage Compensation in Drosophila and Mammals: A Review of the Past and Speculation for the Future
Journal ArticleDOI
Interrelationship between the states of chromosome compaction, replication and transcription patterns in the polytene-X chromosome of Drosophila melanogaster.
TL;DR: Findings while favour a positive correlation between the state of chromosome compaction and replication patterns, are at odds with the idea that for an altered level of transcription, a modulation in the stateof chromosome compACTION and replication is an obligatory pre-requisite.
References
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Gene Action in the X -chromosome of the Mouse ( Mus musculus L.)
TL;DR: Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.
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TL;DR: This is the first attempt since 1925 to publish a comprehensive account of the biology and genetics of Drosophila and it aims to collate the dauntingly large literature on the subject and to make more accessible the private language ot the Dosophilist.
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Two closely linked mutations in drosophila melanogaster that are lethal to opposite sexes and interact with daughterless
TL;DR: A new spontaneous mutation named Sex-lethal, Male-specific No. 1 (SxlM1) is described that is lethal to males, even in the presence of an Sxl+ duplication, and it is suggested that SxLM1 is a constitutive mutation at the Sx l locus.
Journal ArticleDOI
Synthesis of Ribonucleic Acid by the X-Chromosomes of Drosophila melanogaster and the Problem of Dosage Compensation
TL;DR: The identity and equality of genie expression between the two sexes are not associated, a priori, with the development of sex, but rather involves a system of genes, plus and minus modifiers, which regardless of sex tends to repress the action of extra doses of sex-linked genes.
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