Cellular mechanisms and physiological consequences of redox-dependent signalling
Citations
1,809 citations
1,376 citations
Cites background from "Cellular mechanisms and physiologic..."
...Many lines of evidence were accumulating, indicating that ROS and RNS were able to modify proteins in a reversible manner at the level of the sulphur-containing residues, cysteine and methionine, thus providing evidence for the existence of a redox-based signal.(40,49) In particular, reactive cysteine thiol groups (SH) of a growing number of proteins were revealed to be able to rapidly undergo reactions with H2O2 and NO in biological systems, thus forming the S-hydroxylated (S-OH) and S-nitrosylated (S-NO) derivatives, respectively....
[...]
1,260 citations
1,242 citations
1,100 citations
Cites background from "Cellular mechanisms and physiologic..."
...The NOX family were first described in he context of leukocytes where they produce ROS in response to nflammatory mediators [31]....
[...]
...Elevated levels of ROS and O2•− in cancer may be a result of reduced free radical scavenging enzymes, increased glucose metabolism (Warburg effect), increased receptor activity in the cell, oncogenic activity, increased presence of growth factors and cytokines or due to increased intracellular oxidant production from the mitochondria, NADPH oxidases (NOX), cyclooxygenases (COX), lipooxygenases, xanthine oxidases and cytochrome P450 enzymes [3,11,21,31,32]....
[...]
References
7,917 citations
6,371 citations
Additional excerpts
...PtdInsP 3 , phosphatidylinositol (3,4,5)-trisphosphate; SH, thiol; SOH, sulphenic acid....
[...]
4,357 citations
3,985 citations
3,870 citations