Journal ArticleDOI
Cellular response of Escherichia coli to Mg-2Zn-2Gd alloy with different grain structure: mechanism of disruption of colonisation
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It is underscores that grain size had a significant impact on antimicrobial behaviour in magnesium alloys obtained via multiaxial forging.Abstract:
In recent years, magnesium alloys have attracted significant attention as a new class of biodegradable implant materials, because of their superior biocompatibility and low modulus. We describe here the inhibition of bacterial colonisation and biofilm formation on surfaces of Mg-2Zn-2Gd alloy with different grain structures (~44 µm to ~710 nm) obtained via multiaxial forging. Surface energy and contact angle measurements using goniometer and wettability were assessed with water, SBF, n-Hexane and DMEM. The higher surface energy of ultrafine-grained Mg-2Zn-2Gd alloy led to the release of more Mg+2 ions at an early stage, which consequently increased the pH of fluid in the vicinity of the implant, therefore producing unfavourable environment for the survival of Escherichia coli (E. coli) bacteria. This led to damage of bacterial cell walls thereby reducing their adhesion. In summary, the study underscores that grain size had a significant impact on antimicrobial behaviour.read more
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Ultrasonic-assisted CdO–MgO nanocomposite for multifunctional applications
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Lei Huang,Lixun Zhang,Shengwei Xiao,Yin Yang,Feng Chen,Ping Fan,Zhenping Zhao,Mingqiang Zhong,Jintao Yang +8 more
TL;DR: In this paper, a salt-responsive polyzwitterionic brush (poly(3-(dimethyl(4-vinylbenzyl) ammonio) propyl sulfonate), polyDVBAPS) and poly(DVBAP-b-TA) are combined to achieve high bactericidal activity by killing more than 93% and highly efficient regeneration capability by rapidly releasing ∼90% of the attached bacteria.
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Nonleachable Imidazolium-Incorporated Composite for Disruption of Bacterial Clustering, Exopolysaccharide-Matrix Assembly, and Enhanced Biofilm Removal
TL;DR: A new nonleachable antibacterial composite with excellent antibiofilm activity without affecting its mechanical properties is demonstrated, which may serve as a platform for development of alternative antifouling biomaterials.
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Fabrication of magnesium-based metallic scaffolds for bone tissue engineering
TL;DR: Metallic scaffolds for bone tissue engineering including potential metals for tissue engineering scaffold applications are reviewed including production of magnesium scaffold are discussed.
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Salt-responsive “Killing and Release” Antibacterial Surfaces of Mixed Polymer Brushes
Yanhong Fu,Yang Wang,Lei Huang,Shengwei Xiao,Feng Chen,Ping Fan,Mingqiang Zhong,Jun Tan,Jintao Yang +8 more
TL;DR: In this paper, the authors developed a new "killing and release" surface by combining poly[2-(tert-butylamino) ethyl methacrylate] (polyTA) and poly(3-(dimethyl (4-vinylbenzyl) ammonio) propyl sulfonate) (polyDVBAPS) via mixed brushes system.
References
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Journal ArticleDOI
In vivo corrosion of four magnesium alloys and the associated bone response.
Frank Witte,Volker Kaese,Heinz Haferkamp,E. Switzer,Andrea Meyer-Lindenberg,Carl Joachim Wirth,H. Windhagen +6 more
TL;DR: There is a strong rationale that in this research model, high magnesium ion concentration could lead to bone cell activation, and metallic implants made of magnesium alloys degrade in vivo depending on the composition of the alloying elements.
Journal ArticleDOI
In vitro and in vivo corrosion measurements of magnesium alloys.
Frank Witte,J. Fischer,Jens Nellesen,Horst-Artur Crostack,Volker Kaese,Alexander Pisch,Felix Beckmann,H. Windhagen +7 more
TL;DR: Results of this study suggest, that the conclusions drawn from current ASTM standard in vitro corrosion tests cannot be used to predict in vivo corrosion rates of magnesium alloys.
Journal ArticleDOI
The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost.
James D. Whitehouse,N. Deborah Friedman,Kathryn B. Kirkland,William J. Richardson,Daniel J. Sexton +4 more
TL;DR: Orthopedic SSIs prolong total hospital stays by a median of 2 weeks per patient, approximately double rehospitalization rates, and increase healthcare costs by more than 300%.
Journal ArticleDOI
Measurement of the surface free energy of bacterial cell surfaces and its relevance for adhesion.
TL;DR: An experimental technique is described to determine contact angles on bacterial layers deposited on cellulose triacetate filters to calculate interfacial free energies of adhesion of these bacteria from saliva onto tooth surfaces.
Journal ArticleDOI
Alkaline pH homeostasis in bacteria: new insights.
TL;DR: A review of the approaches, major findings and unresolved problems in alkaline pH homeostasis, focusing on the small number of well-characterized alkali-tolerant and extremely alkaliphilic bacteria.