Cellular survival: a play in three Akts
Citations
7,056 citations
5,654 citations
Cites background from "Cellular survival: a play in three ..."
...Foremost among these in the PIP 3 field is AKT, the cellular homologue of the retroviral oncogene v-Akt, which is also known as protein kinase B (PKB; reviewed in Ref...
[...]
3,968 citations
Cites background from "Cellular survival: a play in three ..."
...Another demonstrated target of Akt is IκB (reviewed in Datta et al 1999)....
[...]
...…kinases, phosphatidyl inositides generated by PI-3 kinase activate the protein kinase Akt/protein kinase B. Akt then phosphorylates and controls the biological functions of several proteins important in modulating cell survival (reviewed in Datta et al 1999, Yuan & Yankner 2000)....
[...]
...Many additional proteins in the cell death cascade, including Bcl-2, Apaf-1, caspase inhibitors, and caspases, have a consensus site for Akt phosphorylation but have not been shown to be phosphorylated by this kinase (Datta et al 1999)....
[...]
3,691 citations
Cites background from "Cellular survival: a play in three ..."
...The anti-apoptotic effects of Akt-mediated phosphorylation of these have been extensively reviewe...
[...]
3,254 citations
References
8,757 citations
8,339 citations
6,481 citations
"Cellular survival: a play in three ..." refers background in this paper
...Electrophoretic mobility shift assays indicate that AFX, FKHR, and FKHRL1 bind to the IRS within the IGFBP1 promoter (Brunet et al. 1999; Kops et al. 1999; Tang et al. 1999)....
[...]
...The expression of a constitutively active version of Akt within cells is sufficient to induce the phosphorylation of all three Forkhead isoforms at all three sites (Biggs et al. 1999; Brunet et al. 1999; Kops et al. 1999; Rena et al. 1999)....
[...]
...Since, like BAD, FKHRL1 has been shown to interact with 14-3-3 proteins (Brunet et al. 1999), 14-3-3 may serve as a general chaperone molecule for Akt targets, and may participate in the anchoring of the phosphorylated form of Forkhead transcription factors within the cytoplasm....
[...]
...bers in the cytoplasm has functional consequences for Forkhead-dependent transcription (Biggs et al. 1999; Brunet et al. 1999; Guo et al. 1999; Kops et al. 1999; Tang et al. 1999)....
[...]
...Consistent with this idea, the induction of apoptosis that is triggered by the FKHRL1 phosphorylation site mutant can be reverted when FKHRL1 mutant expressing cells are treated with a soluble form of Fas that acts as a decoy receptor for the newly-synthesized FasL (Brunet et al. 1999)....
[...]
5,831 citations
"Cellular survival: a play in three ..." refers background in this paper
...Several kinases, including PKA, Ca/CaMKII, Ca/CaMK IV, and pp90s, phosphorylate Bad in vitro (Datta et al. 1997; Bonni et al. 1999)....
[...]
...In addition, transfection of 3T3 cells with active Akt alleles is sufficient to induce the phosphorylation of endogenous Bad at Ser-136 (Datta et al. 1997), whereas transfection of cells with dominant–negative Akt alleles blocks phosphorylation of transfected Bad at Ser-136 (Datta et al. 1997; Del…...
[...]
...Consistent with the direct regulation of Bad by Akt, both Bad and Akt coimmunoprecipitate when overexpressed and interact in GST-pulldown experiments (Datta et al. 1997; Blume-Jensen et al. 1998)....
[...]
...…with active Akt alleles is sufficient to induce the phosphorylation of endogenous Bad at Ser-136 (Datta et al. 1997), whereas transfection of cells with dominant–negative Akt alleles blocks phosphorylation of transfected Bad at Ser-136 (Datta et al. 1997; Del Peso et al. 1997; Wang et al. 1999a)....
[...]
...These sites also both lie within consensus sequences that correspond to the Akt phosphorylation site, and Akt was found to potently phosphorylate Bad in vitro (Datta et al. 1997; Del Peso et al. 1997)....
[...]
5,398 citations
"Cellular survival: a play in three ..." refers background in this paper
...It is now clear that the Raf–MEK– MAPK cascade does under some circumstances promote cell survival (Xia et al. 1995; Parrizas et al. 1997; Bergmann et al. 1998; Kurada and White 1998; Meier and Evan 1998; Anderson and Tolkovsky 1999; Bonni et al. 1999; Shimamura et al. 1999)....
[...]