Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis.
Siddharth Singh,Anamay N. Sharma,Mohammad Hassan Murad,Navtej S. Buttar,Hashem B. El–Serag,David A. Katzka,Prasad G. Iyer +6 more
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TLDR
On the basis of a meta-analysis, central adiposity, independent of BMI, is associated with esophageal inflammation (EE), metaplasia (BE), and neoplasia (EAC), and its effects are mediated byReflux-dependent and reflux-independent mechanisms.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-11-01 and is currently open access. It has received 282 citations till now. The article focuses on the topics: Body mass index & Risk factor.read more
Citations
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ACG Clinical Guideline: Diagnosis and Management of Barrett's Esophagus
TL;DR: Endoscopic ablative therapy is recommended for patients with BE and high-grade dysplasia, as well as T1a esophageal adenocarcinoma, and endoscopic surveillance intervals are attenuated, based on recent level 1 evidence.
Journal ArticleDOI
Adiposity and cancer at major anatomical sites: umbrella review of the literature.
Maria Kyrgiou,Maria Kyrgiou,Ilkka Kalliala,Georgios Markozannes,Marc J. Gunter,Evangelos Paraskevaidis,Hani Gabra,Hani Gabra,Pierre Martin-Hirsch,Konstantinos K. Tsilidis,Konstantinos K. Tsilidis +10 more
TL;DR: Obesity is becoming one of the biggest problems in public health; evidence on the strength of the associated risks may allow finer selection of those at higher risk of cancer, who could be targeted for personalised prevention strategies.
Journal ArticleDOI
Presentation and Epidemiology of Gastroesophageal Reflux Disease.
TL;DR: There is substantial overlap between symptoms of GERD and those of eosinophilic esophagitis, functional dyspepsia, and gastroparesis, posing a challenge for patient management.
Journal ArticleDOI
The Epidemiology of Esophageal Adenocarcinoma
TL;DR: The prognosis for patients with EAC has slightly improved, but remains poor, and studies are needed to investigate associations between risk factors and the molecular subtypes of EAC.
Journal ArticleDOI
Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma.
TL;DR: The prognosis is based on tumor stage; patients with T1a tumors have an excellent prognosis, whereas few patients with advanced disease have long-term survival.
References
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Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
Journal Article
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
TL;DR: The QUOROM Statement (QUality Of Reporting Of Meta-analyses) as mentioned in this paper was developed to address the suboptimal reporting of systematic reviews and meta-analysis of randomized controlled trials.
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
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