Journal ArticleDOI
Central biogenic amine metabolism in children with the syndrome of chronic multiple tics of Gilles de la Tourette: norepinephrine, serotonin, and dopamine.
Donald J. Cohen,Bennett A. Shaywitz,J. Gerald Young,Claudia M. Carbonari,James A. Nathanson,Dawn Lieberman,Malcolm B. Bowers,James W. Maas +7 more
TLDR
Reduced accumulation of CSF HVA and 5-HIAA may represent a primary decrease in brain turnover of dopamine and serotonin or a long-term adaptation to overactivity in these systems, perhaps as a result of changes in receptor sensitivity.Abstract:
Central nervous system metabolism in children with the syndrome of Gilles de la Tourette (TS) and contrasting pediatric patients was assessed by measuring the cerebrospinal fluid (CSF) metabolites of dopamine (homovanillic acid, HVA) and serotonin (5-hydroxyindoleacetic acid, 5-HIAA) with and without the administration of probenecid. Reduced accumulation of CSF HVA and 5-HIAA was found in TS. This may represent a primary decrease in brain turnover of dopamine and serotonin or a long-term adaptation to overactivity in these systems, perhaps as a result of changes in receptor sensitivity. In the CSF of a child with profound TS, an elevated level of the major metabolite of norepine.read more
Citations
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Contributions of anterior cingulate cortex to behaviour.
TL;DR: The cingulate epilepsy syndrome provides important support of experimental animal and human functional imaging studies for the role of anterior cingulates cortex in movement, affect and social behaviours.
Journal ArticleDOI
The Domain of Developmental Psychopathology.
L. Alan Sroufe,Michael Rutter +1 more
TL;DR: In this paper, a developmental perspective is presented, and the implications of this perspective for research in developmental psychopathology are discussed, with a focus on individual patterns of adaptation and maladaptation distinguishing this field from the larger discipline of developmental psychology.
Journal ArticleDOI
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization
TL;DR: The determination of the electrophysiological characteristics of a population of cells directly identified as containing a specific neurotransmitter may allow one to construct better models of a system's functioning and may be important functionally with respect to a possible modulatory effect of dopamine in postsynaptic target areas.
Journal ArticleDOI
A functional magnetic resonance imaging study of tic suppression in Tourette syndrome.
Bradley S. Peterson,P Skudlarski,Adam W. Anderson,Heping Zhang,J. C. Gatenby,Cheryl Lacadie,James F. Leckman,John C. Gore +7 more
TL;DR: It is suggested that the pathogenesis of tics involves an impaired modulation of neuronal activity in subcortical neural circuits in anatomically connected cortical regions believed to subserve attention-demanding tasks.
Journal ArticleDOI
Sensory Experiences of Gilles de la Tourette Syndrome
TL;DR: A patient with a 62-year history of Gilles de la Tourette syndrome describes 35 years of self-observation of the subjective events that precede, accompany, and follow the occurrence of symptomatic movements and sounds.
References
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Journal ArticleDOI
Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine.
TL;DR: It is concluded that systemically administered clonidine inhibits the firing of brain NE neurons by acting directly upon adrenergic receptors located on or near the soma of these neurons but that the concomitant inhibition of 5-HT neurons is an indirect effect (possibly secondary to an impairment in noracrenergic transmission).
Journal ArticleDOI
Clonidine blocks acute opiate-withdrawal symptoms
TL;DR: The data suggest that opiate withdrawal is due to increased neuronal activity in areas such as the locus coeruleus which are regulated by both alpha-2 adrenergic and opiate receptors.
Journal ArticleDOI
Studies in vivo on the relationship between brain tryptophan, brain 5‐ht synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and l‐tryptophan
TL;DR: It is suggested that when monoamine oxidase is inhibited and the rate of 5‐HT synthesis is increased, granular uptake and storage of 5-HT and other rate‐limiting mechanisms for 5‐ht inactivation are unable to prevent 5‐ HT 'spilling over’ to produce hyperactivity.
Journal ArticleDOI
Catecholamine receptors on locus coeruleus neurons: pharmacological characterization.
TL;DR: The noradrenergic neurons of the LC appear to possess catecholamine receptors on or near their cell bodies which have pharmacological characteristics of ‘presynaptic’ α-adrenoreceptors in the vicinity of their cell body.