Ceramide-orchestrated signalling in cancer cells
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Cites background from "Ceramide-orchestrated signalling in..."
...PGE2) and phosphoinositides have important signalling functions in cells and tissues (Morad and Cabot, 2013; Wymann and Schneiter, 2008)....
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...Furthermore, sphingolipids, such as ceramide or sphingosine-1-phosphate, eicosanoids (e.g. PGE2) and phosphoinositides have important signalling functions in cells and tissues (Morad and Cabot, 2013; Wymann and Schneiter, 2008)....
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...Enzymes within the sphingolipid metabolism pathway are frequently deregulated in cancer, resulting in lower ceramide levels, which could cause resistance to chemotherapeutic treatment (see Morad and Cabot, 2013; and references therein)....
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...In contrast, sphingosine-1phosphate (S1P) (produced from sphingosine by the action of sphingosine kinases) promotes cell proliferation, migration and angiogenesis (Morad and Cabot, 2013)....
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