Journal ArticleDOI
Cervical cancer control, priorities and new directions.
Joseph Monsonego,F. Xavier Bosch,Pierre Coursaget,John Thomas Cox,Eduardo L. Franco,Ian H. Frazer,Rengaswamy Sankaranarayanan,John T. Schiller,Albert Singer,Torn Wright,Walter Kinney,Chris J.L.M. Meijer,James Linder +12 more
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Although sensitivity and specificity of the available diagnostic techniques are suboptimal, screening for persistent HPV infection is effective in reducing the incidence of cervical cancer.Abstract:
Cervical cancer is caused by infection with a range of high risk oncogenic human papillomavirus (HPV) types, and it is now accepted that >99% of cervical cancer is initiated by HPV infection. The estimated lifetime risk of cervical cancer is nevertheless relatively low (less than I in 20 for most community based studies). Although sensitivity and specificity of the available diagnostic techniques are suboptimal, Screening for persistent HPV infection is effective in reducing the incidence of cervical cancer. Infection can be detected by molecular techniques or by cytological examination of exfoliated cervical cells. Persistent infection is the single best predictor of risk of cervical cancer.(1) The latest findings of HPV and cervical cancer research need to be widely disseminated to the scientific and medical societies that are updating screening and management protocols, public health professionals, and to women and clinicians. This report reviews current evidence, clinical implications and directions for further research in the prevention, control and management of cervical cancer. We report the conclusions of the Experts' Meeting at the EUROGIN 2003 conference. (C) 2003 Wiley-Liss, Inc.read more
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Guidelines for Preventive Activities in General Practice
Evan Ackermann,Mark Harris,Karen Alexander,Meredith Arcus,Linda Bailey,John W. Bennett,Chris Del Mar,Jon Emery,Ben Ewald,Dan Ewald,Michael Fasher,John Furler,Faline Howes,Caroline Johnson,Beres Joyner,John Litt,Danielle Mazza,Dimity Pond,Jane Smith,Tania Winzenberg +19 more
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Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity
TL;DR: The widespread nature of HPV infection requires greater understanding of both the HPV life cycle as well as the mechanisms underlying HPV‐induced carcinogenesis.
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Screen-and-treat approaches for cervical cancer prevention in low-resource settings: a randomized controlled trial.
TL;DR: Both screen-and-treat approaches for cervical cancer prevention are safe and result in a lower prevalence of high-grade cervical cancer precursor lesions compared with delayed evaluation at both 6 and 12 months.
Journal ArticleDOI
Epidemiology of cervical cancer with special focus on India
TL;DR: This paper attempts to review the available knowledge regarding the epidemiology and pattern of cervical cancer; types of HPV prevalent among cervical cancer patients and among women in general, high-risk groups such as commercial sex workers, and HIV (human immunodeficiency virus)-positive women; and the role of the national program on cancer in control efforts.
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Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé,Rolando Herrero,Xavier Castellsagué,Keerti V. Shah,Peter J.F. Snijders,Chris J.L.M. Meijer +7 more
TL;DR: In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
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The causal relation between human papillomavirus and cervical cancer
TL;DR: It is the right time for medical societies and public health regulators to consider the causal role of human papillomavirus infections in cervical cancer and to define its preventive and clinical implications.
Journal ArticleDOI
A controlled trial of a human papillomavirus type 16 vaccine.
Laura A. Koutsky,Kevin A. Ault,Cosette M. Wheeler,Darron R. Brown,Eliav Barr,Frances B. Alvarez,Lisa M. Chiacchierini,Kathrin U. Jansen +7 more
TL;DR: Administration of this HPV- 16 vaccine reduced the incidence of both HPV-16 infection and HPV-15-related cervical intraepithelial neoplasia, and immunizing HPV-14-negative women may eventually reduce the probability of cervical cancer.