Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases
Citations
115 citations
Cites background from "Challenges in the Development of a ..."
...Thiol-containing compounds inhibit all MBL subtypes (B1, B2, and B3) (168), with strong competitive inhibition of IMP-1 by thioester derivatives first being reported in 1999 (169)....
[...]
...Figure 1 illustrates the amino acid residues that bind zinc at the active sites of B1, B2, and B3 MBLs (8)....
[...]
...Thiol-containing compounds inhibit all MBL subtypes (B1, B2, and B3) (168), with...
[...]
...Accepted manuscript posted online 20 July 2020 Published October 2020 Volume 64 Issue 10 e00397-20 aac.asm.org 1Antimicrobial Agents and Chemotherapy 21 September 2020 Class B enzymes are further divided into three subclasses—B1, B2, and B3— based on differences in amino acid sequence at the active site, zinc ligands, zinc stoichiometry, loop architecture, and substrate profiles (8)....
[...]
102 citations
100 citations
97 citations
68 citations
References
27,505 citations
18,531 citations
12,206 citations
560 citations
472 citations