Challenges translating breast cancer gene signatures into the clinic
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Cites background from "Challenges translating breast cance..."
...Tumors resistant to therapeutic agents usually bear a “convergent phenotype,” in which multiple di erent genetic and epigenetic aberrations may potentially cause resistance to a particular agent (5, 6)....
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References
14,768 citations
"Challenges translating breast cance..." refers background in this paper
...In breast cancer, a microarray-based study by the Stanford grou...
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10,791 citations
"Challenges translating breast cance..." refers result in this paper
...Analysis of larger independent datasets subsequently confirmed the existence of similar but not identical subgroups, and demonstrated that ER-positive cancers could be further subdivided into at least two subgroups, luminal A and B, which correlated with a difference in prognosis...
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9,664 citations
"Challenges translating breast cance..." refers background in this paper
...4,5 The strongest evidence for this does not come from the molecular-classification literature but from results obtained with prognostic gene signatures that were empirically developed to distinguish good-prognosis from poor-prognosis cancers (Oncotype DX® and MammaPrint®).(20,21) These signatures can be used to define which patients with ER-positive breast cancer should receive adjuvant chemotherapy....
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9,493 citations
"Challenges translating breast cance..." refers methods in this paper
...Similar approaches have been employed in the study of lymphomas...
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6,309 citations