Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain?
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Cites background from "Challenging the omnipotence of the ..."
...As a master pacemaker, the SCN synchronizes other oscillators throughout the brain (50) and peripheral tissues (10)....
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...The SCN also generates pronounced circadian rhythms in frequency of spontaneous neuronal firing when physically isolated, either in vivo (46) or in vitro (47–49), although recent data indicate this may not be a unique property (50)....
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Cites background from "Challenging the omnipotence of the ..."
...However, KLF10 is implicated in circadian lipid and cholesterol homeostasis in females (Guillaumond et al., 2010)....
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...Interestingly, Tieg1/Klf10 is regulated by BMAL1/ CLOCK and thus appears to be part of a feedback loop involving the circadian clock and glucose levels (Guillaumond et al., 2010) (Figure 4)....
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Cites background or methods from "Challenging the omnipotence of the ..."
...Proceeding in general terms, we assume the oscillator can be characterized by its amplitude, its intrinsic period and its stability with respect to amplitude perturbations (amplitude relaxation rate or Floquet exponent (Guckenheimer and Holmes, 1983))....
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...We find that increasing coupling strength leads to a drastic increase of the amplitude most pronounced for small values of g, the relaxation rate of the individual oscillators (Figure 5A)—a well-known resonance phenomenon (Guckenheimer and Holmes, 1983)....
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...Our results for the generic Poincaré oscillator also hold for other oscillator models, such as the standard Hopf oscillator (Guckenheimer and Holmes, 1983) or the more realistic biophysical circadian clock Becker-Weimann–Bernard model (Becker-Weimann et al, 2004; Bernard et al, 2007) (see…...
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References
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"Challenging the omnipotence of the ..." refers methods in this paper
...Schematic sections are adapted from the rat brain atlas of Paxinos & Watson (1998)....
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3,962 citations
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...The mechanism has been extensively reviewed (Dunlap, 1999; Hastings & Maywood, 2000; Piggins, 2002; Reppert & Weaver, 2002; Albrecht, 2004; Ko & Takahashi, 2006) and, it is postulated, functions as follows: basic helix–loop–helix transcription factors Bmal1 and Clock provide the positive drive to…...
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...…ª Federation of European Neuroscience Societies and Blackwell Publishing Ltd European Journal of Neuroscience, 25, 3195–3216 lags between transcription, translation and translocation of proteins from the cytoplasm to the nucleus (Lee et al., 2001; Reppert & Weaver, 2002; Lee et al., 2004)....
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...Mutations of these genes result in various behavioural phenotypes indicative of altered clock function, such as arrhythmicity or changes in period length (for a review see Reppert & Weaver, 2002)....
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2,723 citations
"Challenging the omnipotence of the ..." refers background in this paper
...The mechanism has been extensively reviewed (Dunlap, 1999; Hastings & Maywood, 2000; Piggins, 2002; Reppert & Weaver, 2002; Albrecht, 2004; Ko & Takahashi, 2006) and, it is postulated, functions as follows: basic helix–loop–helix transcription factors Bmal1 and Clock provide the positive drive to…...
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2,107 citations
"Challenging the omnipotence of the ..." refers background in this paper
...It functions to integrate emotion, cognition and autonomic signals and is crucial to the perception of and responses to fear, stress and drugs of abuse (Gallagher & Chiba, 1996; Maren & Fanselow, 1996; Rasia-Filho et al., 2000; LeDoux, 2003; See et al., 2003; McGaugh, 2004; Phelps & LeDoux, 2005)....
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