Changes in alanine transaminase activity in the liver of riboflavin-deficient rats.
TL;DR: Befunde weisen darauf hin, dass die Aktivität der Nebennierenrinde beim Riboflavinmangel erhöht ist.
Abstract: 45tagiger Riboflavinmangel bewirkte bei mannlichen Albinoratten in der Leber eine Erhohung der Alanin-Transaminase-Aktivitat sowie des Pyridoxal- und Glykogengehaltes. Diese Befunde weisen darauf hin, dass die Aktivitat der Nebennierenrinde beim Riboflavinmangel erhoht ist.
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TL;DR: Parenteral administration of pyridoxal 5′-phosphate (PALP) to rib oflavin-deficient rats increased the non-FAD component of erythrocyte riboflavin and in vitro stimulation of the enzyme with FAD was decreased, but not by treatment with pyrsidoxine.
Abstract: 1. Parenteral administration of pyridoxal 5′-phosphate (PALP) to riboflavin-deficient rats increased the non-FAD component of erythrocyte riboflavin.2. Pyridoxaminephosphate oxidase (EC 1.4.3.5) activity in the livers of riboflavin-deficient animals was only 15% of that of controls. PALP concentration in blood, liver and brain was not affected. Deficient animals had higher levels of pyridoxine in liver.3. Human subjects with lesions of the mouth responded to treatment with either riboflavin or pyridoxine.4. PALP concentration of human blood was not affected by administration of riboflavin but was markedly increased by pyridoxine.5. Erythrocyte glutathione reductase activity (EC 1.6.4.2) in humans was increased and in vitro stimulation of the enzyme with FAD was decreased by treatment with riboflavin, but not by treatment with pyridoxine.
26 citations
01 Jan 1975
TL;DR: The endocrine glands play an important role in the control of various aspects of riboflavin metabolism, including the conversion of the vitamin into its active coenzyme derivatives, FMN and FAD, which is subject to hormonal regulation.
Abstract: The endocrine glands play an important role in the control of various aspects of riboflavin metabolism. The conversion of the vitamin into its active coenzyme derivatives, FMN and FAD, is subject to hormonal regulation. Hormones influence the metabolic utilization of the vitamin, the magnitude of tissue concentrations, the rate of excretion in urine, and, in certain species, the transport of the vitamin in plasma. Disturbances in the metabolism of riboflavin accompany endocrine disorders both in experimental animals and in man.
10 citations
TL;DR: The results are discussed as suggestive of enhanced and reduced protein synthesis in the mitochondrial and microsomal fractions, respectively, of riboflavine-deficient rats.
Abstract: 1. The effect of riboflavine deficiency on in vivo incorporation of [2–14C]glycine into proteins of liver homogenates and its subcellular fractions has been studied on rats maintained on a 16 % protein diet. 2. Riboflavine deficiency did not seem to affect the in vivo incorporation of [2–14C]g1ycine into proteins of liver homogenates. But riboflavine deficiency caused increased and reduced invivo incorporation of [14C]amino acid into mitochondrial and microsomal proteins, respectively.There was no significant change in the in vivo incorporation of [14C]amino acid into proteins ofnuclear, ribosomal and soluble fractions in riboflavine deficiency. 3. Riboflavine deficiency caused enhanced and reduced proportions of liver mitochondrial and microsomal proteins, respectively. 4. The results are discussed as suggestive of enhanced and reduced protein synthesis in the mitochondrial and microsomal fractions, respectively, of riboflavine-deficient rats.
8 citations
01 Jan 1980
TL;DR: This paper will review the clinical significance of riboflavin deficiency with a special emphasis being given to recently acquired information.
Abstract: The clinical consequences of riboflavin deficiency in humans were first described by Sebrell and Butler (1938). On a diet which furnished only 0.5 mg of riboflavin daily, 10 of 18 adult women developed oral lesions that disappeared following riboflavin supplementation. Now, over 40 years later, riboflavin deficiency is recognized as a global health problem that can occur in persons of any race, sex or age. Much new knowledge about riboflavin has been obtained during the last 10 years due to major improvements in methods for measuring riboflavin status and a concomitant renewed interest in nutrition. This paper will review the clinical significance of riboflavin deficiency with a special emphasis being given to recently acquired information.
5 citations
TL;DR: Männliche Albino-Ratten zeigten erhöhten Glykogengehalt in der Leber verbunden mit einer gesteigerten Aufnahme von C14 aus Alanin-1-C14 im Leberglykogen.
Abstract: Mannliche Albino-Ratten, die wahrend 45 Tagen mit Riboflavin-armer Kost ernahrt wurden, zeigten erhohten Glykogengehalt in der Leber, verbunden mit einer gesteigerten Aufnahme von C14 aus Alanin-1-C14 im Leberglykogen. Die Befunde lassen auf erhohte Glykoneogenese in der Leber Riboflavin-armer Ratten schliessen.
5 citations