Journal ArticleDOI
Changes in the permeability of the testicular capillaries and of the 'blood-testis barrier' after injection of cadmium chloride in the rat
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This article is published in Journal of Endocrinology.The article was published on 1970-05-01. It has received 132 citations till now. The article focuses on the topics: Cadmium chloride & Serum albumin.read more
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Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis
Dolores D. Mruk,C. Yan Cheng +1 more
TL;DR: This review focuses on the process by which a single spermatogonium develops into 256 spermatozoa, one of which will fertilize the ovum, and recaps recent developments in the field.
Journal ArticleDOI
The Blood-Testis Barrier and Its Implications for Male Contraception
C. Yan Cheng,Dolores D. Mruk +1 more
TL;DR: Multiple potential targets are present at the BTB for innovative contraceptive development and for better delivery of drugs to alleviate toxicant-induced reproductive dysfunction in men, as well as critically evaluate findings in the field regarding studies on drug transporters in the testis.
Journal ArticleDOI
Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development
C. Yan Cheng,Dolores D. Mruk +1 more
TL;DR: The physiology and biology of junction dynamics in the testis, in particular how these events affect interactions of Sertoli and germ cells in the seminiferous epithelium behind the blood-testis barrier are discussed.
Journal ArticleDOI
Cadmium-induced testicular injury.
TL;DR: This review critically discusses recent data in the field that have demonstrated the Cd-induced toxicity to the testis is probably the result of interactions of a complex network of causes and sheds lights on potential therapeutic or preventive approaches that can be developed in future studies by blocking or minimizing the destructive effects of Cd to testicular function in men.
Journal ArticleDOI
Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis
Timothy P. Dalton,Lei He,Bin Wang,Marian L. Miller,Li Jin,Keith F. Stringer,Xiaoqing Chang,C. Stuart Baxter,Daniel W. Nebert +8 more
TL;DR: It is shown here that ZRT-, IRT-like protein (ZIP)8 expression in cultured mouse fetal fibroblasts leads to a >10-fold increase in the rate of intracellular Cd influx and accumulation and 30- fold increase in sensitivity to Cd-induced cell death.
References
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Journal ArticleDOI
Regional blood flow by fractional distribution of indicators.
TL;DR: K42 Cl, Rb86Cl and iodoantipyrine were given in single intravenous injections to rats and the isotope content of the organs and the arterial blood concentrations were studied as a function of isotopes.
Journal ArticleDOI
A blood-testis barrier restricting passage from blood into rete testis fluid but not into lymph.
TL;DR: A permeability barrier in or around the seminiferous tubules of rams has been demonstrated by studying the rate of passage of a variety of substances from blood plasma into fluid collected from the rete testis and into testicular lymph.
Journal Article
The selective injurious response of testicular and epididymal blood vessels to cadmium and its prevention by zinc
TL;DR: Experimental evidence is furnished for the premise that endothelium may have a morphologic organ speciflcity'' with different reactions to various forms of injury with different responses to cadmium.
Journal ArticleDOI
Observations on the early events of cadmium necrosis of the testis
TL;DR: The fact that the earliest alterations are observed in blood vessels suggests that the site of action of cadmium in the production of testicular necrosis is upon the endothelium of the vascular bed.
Related Papers (5)
Regulation of blood-testis barrier dynamics: an in vivo study
The Blood-Testis Barrier and Its Implications for Male Contraception
C. Yan Cheng,Dolores D. Mruk +1 more
Is cadmium chloride-induced inter-sertoli tight junction permeability barrier disruption a suitable in vitro model to study the events of junction disassembly during spermatogenesis in the rat testis?
Nancy P. Y. Chung,C. Yan Cheng +1 more