Book ChapterDOI
Chapter 3 – Antimicrobial magnetosomes for topical antimicrobial therapy
T. Revathy,M. A. Jayasri,K. Suthindhiran +2 more
- pp 67-101
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TLDR
The carrier property of magnetosomes and antimicrobial activity of drugs/natural compound combination is a successful approach for the prevention of microbial biofilm formation.Abstract:
Biofilms are microbial communities which survive in the hostile environment and are highly resistant to various antimicrobial agents and so very difficult to control, which leads to severity infections. There is an urgent need to eradicate these biofilm-forming bacteria. Nanomedicine is an emerging trend in the medical field, as nanoparticles have been well documented for their antagonistic activity against bacteria, fungi, and viruses and has given rise to new insights in antibiofilm research. Nanomaterials such as silver, gold, aluminum, titanium, iron, and zinc are known to inhibit microbial biofilm. However, they are toxic to the host cells and also to the ecosystem. Magnetosomes produced by magnetotactic bacteria are the iron crystals covered by a lipid membrane called magnetosome membrane. This makes them highly unique compared to the synthetic magnetic nanoparticles. Magnetosomes have received much attention due to their low toxicity, ecofriendly, and cost-efficient properties. Magnetosomes are capable of penetrating the biofilm matrix. Magnetosomes in combination with antibiotics/essential oils will be highly proficient in enhancing the wound-healing property. The carrier property of magnetosomes and antimicrobial activity of drugs/natural compound combination is a successful approach for the prevention of microbial biofilm formation.read more
Citations
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Reverse micelle-lipid nanocapsules: a novel strategy for drug delivery of the plectasin derivate AP138 antimicrobial peptide.
TL;DR: This study shows that RM-LNCs are an excellent candidate system to deliver AMPs, resulting in protection against degradation by proteases and the preservation of antimicrobial activity against Staphylococcus aureus, including methicillin-resistant
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Ebrahim Mostafavi,Ebrahim Mostafavi,Ebrahim Mostafavi,David Medina-Cruz,Ada Vernet-Crua,Junjiang Chen,Jorge L. Cholula-Díaz,Grégory Guisbiers,Thomas J. Webster +8 more
TL;DR: An overview of the current situation for treating brain tumors using nanotechnological-based approaches is introduced, and some of the latest advances in the application of green nanomaterials (NMs) for the effective targeting of brain tumors are presented.
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A comparison of different strategies for antimicrobial peptides incorporation onto/into lipid nanocapsules.
Nada Matougui,Anne-Claire Groo,Anita-Monika Umerska,Anita-Monika Umerska,Viviane Cassisa,Patrick Saulnier +5 more
TL;DR: A lipid nanocapsule-based platform appears suitable to deliver AMPs, and the covalent attachment strategy turned out to be less conclusive due to peptide inactivation.
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Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562)
Paulo Emilio Feuser,Paula Christina Matos dos Santos,Arthur Poester Cordeiro,Natália Marceli Stefanes,Laura Otto Walter,Mariana Franzoni Maioral,Maria Cláudia Santos-Silva,Pedro Henrique Hermes de Araújo,Claudia Sayer +8 more
TL;DR: Poly(thioether-ester) (PTEe), a polymer synthesized from renewable monomers, is a promising alternative for the encapsulation of antitumor drugs due to its biocompatibility and biodegradability and can be a new tool for the treatment of neoplastic cells.
References
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Journal ArticleDOI
Essential oils: their antibacterial properties and potential applications in foods--a review.
TL;DR: In vitro studies have demonstrated antibacterial activity of essential oils (EOs) against Listeria monocytogenes, Salmonella typhimurium, Escherichia coli O157:H7, Shigella dysenteria, Bacillus cereus and Staphylococcus aureus at levels between 0.2 and 10 microl ml(-1).
Journal ArticleDOI
The biofilm matrix
TL;DR: The functions, properties and constituents of the EPS matrix that make biofilms the most successful forms of life on earth are described.
Journal ArticleDOI
Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria
Ivan Sondi,Branka Salopek-Sondi +1 more
TL;DR: These nontoxic nanomaterials, which can be prepared in a simple and cost-effective manner, may be suitable for the formulation of new types of bactericidal materials.
Journal ArticleDOI
A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus.
TL;DR: The existence of elements of silver and sulfur in the electron-dense granules and cytoplasm detected by X-ray microanalysis suggested the antibacterial mechanism of silver: DNA lost its replication ability and the protein became inactivated after Ag(+) treatment.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.