Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
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TLDR
Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for dAbstract:
Background: Hospitalised COVID-19 patients are frequently elderly subjects with co-morbidities receiving polypharmacy, all of which are known risk factors for dread more
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Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
Philippe Gautret,Jean-Christophe Lagier,Philippe Parola,Van Thuan Hoang,Line Meddeb,M. Mailhe,Barbara Doudier,Johan Courjon,Valérie Giordanengo,Vera Esteves Vieira,Hervé Tissot Dupont,Stéphane Honoré,Philippe Colson,Eric Chabrière,Bernard La Scola,Jean-Marc Rolain,Philippe Brouqui,Didier Raoult +17 more
TL;DR: Hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin, which was significantly more efficient for virus elimination.
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Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study.
Tao Chen,Di Wu,Huilong Chen,Weiming Yan,Danlei Yang,Guang Chen,Ke Ma,Dong Xu,Haijing Yu,Hongwu Wang,Tao Wang,Wei Guo,Jia Chen,Chen Ding,Xiaoping Zhang,Jiaquan Huang,Meifang Han,Shusheng Li,Xiaoping Luo,Jianping Zhao,Qin Ning +20 more
TL;DR: Severe acute respiratory syndrome coronavirus 2 infection can cause both pulmonary and systemic inflammation, leading to multi-organ dysfunction in patients at high risk, including patients with cardiovascular comorbidity.
Journal ArticleDOI
Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19).
Tao Guo,Yongzhen Fan,Ming Chen,Xiaoyan Wu,Lin Zhang,Tao He,Hairong Wang,Jing Wan,Xinghuan Wang,Zhibing Lu +9 more
TL;DR: This case series study evaluates the association of underlying cardiovascular disease and myocardial injury on fatal outcomes in patients with coronavirus disease 2019 (COVID-19).
Journal ArticleDOI
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.
Alba Grifoni,Daniela Weiskopf,Sydney I. Ramirez,Sydney I. Ramirez,Jose Mateus,Jennifer M. Dan,Jennifer M. Dan,Carolyn Rydyznski Moderbacher,Stephen A. Rawlings,Aaron Sutherland,Lakshmanane Premkumar,Ramesh Jadi,Daniel Marrama,Aravinda M. de Silva,April Frazier,Aaron F. Carlin,Jason A. Greenbaum,Bjoern Peters,Bjoern Peters,Florian Krammer,Davey M. Smith,Shane Crotty,Shane Crotty,Alessandro Sette,Alessandro Sette +24 more
TL;DR: Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS.
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Persistent Symptoms in Patients After Acute COVID-19.
TL;DR: This case series describes COVID-19 symptoms persisting a mean of 60 days after onset among Italian patients previously discharged from CO VID-19 hospitalization.
References
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Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak.
TL;DR: Public health measures were decisive in controlling the SARS epidemic in 2003 but whether these measures will be sufficient to control 2019-nCoV depends on addressing some unanswered questions.
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Risk for Transportation of Coronavirus Disease from Wuhan to Other Cities in China.
Zhanwei Du,Lin Wang,Simon Cauchemez,Xiaoke Xu,Xianwen Wang,Benjamin J. Cowling,Lauren Ancel Meyers,Lauren Ancel Meyers +7 more
TL;DR: The probability of transportation of COVID-19 from Wuhan to 369 other cities in China before the quarantine is estimated to be >50% in 130 (95% CI 89–190) cities and >99% in the 4 largest metropolitan areas.
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SARS to novel coronavirus - old lessons and new lessons.
Brian McCloskey,David L Heymann +1 more
TL;DR: The response to the novel coronavirus outbreak in China suggests that many of the lessons from the 2003 SARS epidemic have been implemented and the response improved as a consequence, but some questions remain and not all lessons have been successful.
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2019-novel Coronavirus (2019-nCoV): estimating the case fatality rate - a word of caution.
Manuel Battegay,Richard Kuehl,Sarah Tschudin-Sutter,Hans H. Hirsch,Andreas F. Widmer,Richard A. Neher +5 more
TL;DR: It is tempting to estimate the case fatality rate by dividing the number of known deaths by theNumber of confirmed cases, however, the resulting number does not represent the true casefatality rate and might be off by orders of magnitude.
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