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Characteristics of and public health responses to the coronavirus disease 2019 outbreak in China

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TLDR
The Chinese Government has initiated a level-1 public health response to prevent the spread of the disease, and it is also crucial to speed up the development of vaccines and drugs for treatment, which will enable us to defeat COVID-19 as soon as possible.
Abstract
In December 2019, cases of unidentified pneumonia with a history of exposure in the Huanan Seafood Market were reported in Wuhan, Hubei Province. A novel coronavirus, SARS-CoV-2, was identified to be accountable for this disease. Human-to-human transmission is confirmed, and this disease (named COVID-19 by World Health Organization (WHO)) spread rapidly around the country and the world. As of 18 February 2020, the number of confirmed cases had reached 75,199 with 2009 fatalities. The COVID-19 resulted in a much lower case-fatality rate (about 2.67%) among the confirmed cases, compared with Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Among the symptom composition of the 45 fatality cases collected from the released official reports, the top four are fever, cough, short of breath, and chest tightness/pain. The major comorbidities of the fatality cases include hypertension, diabetes, coronary heart disease, cerebral infarction, and chronic bronchitis. The source of the virus and the pathogenesis of this disease are still unconfirmed. No specific therapeutic drug has been found. The Chinese Government has initiated a level-1 public health response to prevent the spread of the disease. Meanwhile, it is also crucial to speed up the development of vaccines and drugs for treatment, which will enable us to defeat COVID-19 as soon as possible.

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The psychological impact of the COVID-19 epidemic on college students in China.

TL;DR: Having relatives or acquaintances infected with COVID-19 was a risk factor for increasing the anxiety of college students and economic effects, and effects on daily life, as well as delays in academic activities, were positively associated with anxiety symptoms.
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Characteristics of SARS-CoV-2 and COVID-19

TL;DR: The basic virology of SARS-CoV-2 is described, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses.
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Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center's observational study.

TL;DR: In this series of severe pediatric patients in Wuhan, polypnea was the most common symptom, followed by fever and cough, and a cytokine storm was found in these patients, which appeared more serious in critically ill patients.
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SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development.

TL;DR: This review briefly summarized the current advances in SARS-CoV-2 research, including the epidemic situation and epidemiological characteristics of the caused disease COVID-19, and introduced the protein structures and structure-based therapeutics development including antibodies, antiviral compounds, and vaccines.
References
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Journal ArticleDOI

A Novel Coronavirus from Patients with Pneumonia in China, 2019.

TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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