Chemical Functionalization of Nanodiamond for Nanobiomedicine
26 Aug 2020-pp 229-246
About: The article was published on 2020-08-26. It has received 5 citations till now. The article focuses on the topics: Nanodiamond.
Citations
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Journal Article•
TL;DR: It is shown that bright fluorescent nanodiamonds can be produced in large quantities by irradiating synthetic diamond nanocrystallites with helium ions, and the fluorescence is sufficiently bright and stable to allow three-dimensional tracking of a single particle within the cell by means of either one- or two-photon-excited fluorescence microscopy.
Abstract: Fluorescent nanodiamond is a new nanomaterial that possesses several useful properties, including good biocompatibility1, excellent photostability1,2 and facile surface functionalizability2,3. Moreover, when excited by a laser, defect centres within the nanodiamond emit photons that are capable of penetrating tissue, making them well suited for biological imaging applications1,2,4. Here, we show that bright fluorescent nanodiamonds can be produced in large quantities by irradiating synthetic diamond nanocrystallites with helium ions. The fluorescence is sufficiently bright and stable to allow three-dimensional tracking of a single particle within the cell by means of either one- or two-photon-excited fluorescence microscopy. The excellent photophysical characteristics are maintained for particles as small as 25 nm, suggesting that fluorescent nanodiamond is an ideal probe for long-term tracking and imaging in vivo, with good temporal and spatial resolution.
643 citations
01 Jan 2010
TL;DR: In this paper, multistep organictransformations of nanodiamond (ND) nanoparticles were presented, with the objective of enabling covalent bonding with introduced functionalities.
Abstract: Imparting multiple functions to nanoparticles through organic functionalization has beenattracting significant interest, particularly in terms of biomedical applications. Among them,diamond nanoparticles;the so-called nanodiamond (ND);have been recognized as one of thebestplatforms,becauseofitsnontoxicorlow-toxicityproperties,aswellasitsorganiccharacteristicsthat enable covalent bonding with introduced functionalities. Here, we show multistep organictransformationsontheNDsurfacethatamasstherequisitefunctionslayerbylayerthroughcovalentbonds.ThefunctionalitiesintroducedontotheNDsurfacewerewell-characterizedbysolution-phase
68 citations
TL;DR: In this article, a detonation nanodiamond (DND) with manganese ions directly grafted to its surface was presented, and the distance between Mn2+ ion and diamond surface was estimated from the 13C NMR relaxation data.
9 citations
TL;DR: In this paper , an analysis of the 1H and 13C spin-lattice and spin-spin relaxation times and rates in aqueous suspensions of purified nanodiamonds produced by detonation technique (DNDs), DNDs with grafted paramagnetic ions, and micro-and nanidiamonds manufactured by milling bulk high-temperature high-pressure diamonds is presented.
Abstract: An analysis of our data on 1H and 13C spin–lattice and spin–spin relaxation times and rates in aqueous suspensions of purified nanodiamonds produced by detonation technique (DNDs), DNDs with grafted paramagnetic ions, and micro- and nanodiamonds produced by milling bulk high-temperature high-pressure diamonds is presented. It has been established that in all the studied materials, the relaxation rates depend linearly on the concentration of diamond particles in suspensions, the concentration of grafted paramagnetic ions, and surface paramagnetic defects produced by milling, while the relaxation times exhibit a hyperbolic dependence on the concentration of paramagnetic centers. This is a universal law that is valid for suspensions, gels, and solids. The results obtained will expand the understanding of the properties of nano- and microdiamonds and will be useful for their application in quantum computing, spintronics, nanophotonics, and biomedicine.
TL;DR: In this paper , electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) studies were performed on DNDs synthesized from a few nonconventional explosives, which have not previously been used for this purpose.
References
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TL;DR: The rational control of the mechanical, chemical, electronic and optical properties of nanodiamonds through surface doping, interior doping and the introduction of functional groups are discussed.
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