Chemically defined media for commercial fermentations
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1,074 citations
Cites background from "Chemically defined media for commer..."
...Thus, synthetic media provides better control and monitoring, improved product recovery and quality, and simplified purification systems (Zhang and Greasham, 1999)....
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375 citations
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Cites background from "Chemically defined media for commer..."
...Chemically de®ned media (for review see Zhang and Greasham 1999) simplify feeding strategies because they are associated with known yield coe cients, growth rates etc....
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298 citations
References
3,546 citations
"Chemically defined media for commer..." refers methods in this paper
...…those variables (three to ®ve) that have a signi®cant e ect on the desired response from a larger number of potential variables (more than ®ve) with a minimum of testing, employing fractional factorial designs such as the Plackett-Burman method (Plackett and Burman 1946; Roseiro et al. 1992)....
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1,303 citations
"Chemically defined media for commer..." refers methods in this paper
...Another popular and easy-to-use optimization strategy is the sequential simplex method (Spendley et al. 1962; Leggett 1983), in which the optimum area is located through a series of sequential moves toward the better responses....
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1,072 citations
"Chemically defined media for commer..." refers background in this paper
...Regulatory and GMP compliance The recently publicized bovine spongiform encephalopathy (BSE) issue, or mad cow disease (Wells et al. 1987; Bastian 1993), has prompted the regulatory authorities in Europe and the United States to establish various guidelines banning the use of some beef-derived raw…...
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882 citations
470 citations
Additional excerpts
...There are a number of reports describing production of the interested metabolites in de®ned media comparable to that in complex media (Van de Rijn and Kessler 1980; Wessman 1982; Fein et al. 1983; Blumentals et al. 1987; Hensing et al. 1995)....
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