Journal ArticleDOI
Chemistry and antiviral activities of acyclonucleosides
Chung K. Chu,Stephen J. Cutler +1 more
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In this paper, a synthese sur les acyclonucleosides derives de purine ou de pyrimidine and les acYclo-C-nucleoside.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1986-03-01. It has received 269 citations till now. The article focuses on the topics: Amidine.read more
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Computer-assisted structure-activity correlations of dideoxynucleoside analogs as potential anti-HIV drugs.
Patent
Antiretroviral enantiomeric nucleotide analogs
TL;DR: Resolved enantiomers of formulae (IA) and (IB) wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections as mentioned in this paper.
Journal ArticleDOI
Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines.
Aymn E. Rashad,Mohamed I. Hegab,Randa E. Abdel-Megeid,Nahed Fathalla,Farouk M. E. Abdel-Megeid +4 more
TL;DR: Preparation of some novel substituted pyrazole and pyrazolo[3,4-d]pyrimidine derivatives revealed promising antiviral activity against herpes simplex virus type-1 in comparison to Acyclovir as a control.
Journal ArticleDOI
Synthesis and antiviral evaluation of novel 5-(N-Aryl-aminomethyl-1,3,4-oxadiazol-2-yl)hydrazines and their sugars, 1,2,4-triazoles, tetrazoles and pyrazolyl derivatives.
TL;DR: A number of new N‐arylaminomethyl‐1,3,4‐oxadiazole derivatives 2, 3a,b, and 9–12a, b showed higher antiviral activity compared to the other hydrazones and their acetylated derivatives.
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Journal ArticleDOI
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine
Gertrude B. Elion,Phillip A. Furman,James A. Fyfe,Paulo de Miranda,Lilia M. Beauchamp,Howard J. Schaeffer +5 more
TL;DR: Acycloguanosine triphosphate inhibits herpes simplex virus DNA polymerase (DNA nucleotidyltransferase) 10-30 times more effectively than cellular (HeLa S3) DNA polymerases, contributing to the drug's selectivity.
Journal ArticleDOI
9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group
Howard J. Schaeffer,Lilia M. Beauchamp,P de Miranda,Gertrude B. Elion,D. J. Bauer,Pamela Y. Collins +5 more
TL;DR: Of a series of nucleoside analogues synthesized, 9-(2-hydroxy-ethoxymethyl)guanine was found to have marked antiviral activity in animal models of herpes virus infections, associated with very low toxicity.
Journal ArticleDOI
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.
TL;DR: In animal model systems (namely, cutaneous herpes infections of athymic nude mice), (E)-5-(2-bromovinyl)-dUrd suppressed the development of herpetic skin lesions and mortality therewith associated, whether the compound was administered topically or systemically.
Journal ArticleDOI
9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication
A. K. Field,M.-E. M. Davies,C. M. Dewitt,Helen C. Perry,R. Liou,John I. Germershausen,John D. Karkas,W. T. Ashton,D. B. R. Johnston,Richard L. Tolman +9 more
TL;DR: 2'NDG was at least 10-fold more potent than acyclovir (ACV) in inhibition of human cytomegalovirus replication and Epstein-Barr virus-induced lymphocyte transformation and was about as effective as ACV in inhibited of herpes simplex viruses 1 and 2 and varicella zoster virus.
Journal ArticleDOI
Tight-binding inhibitors-IV. Inhibition of adenosine deaminases by various inhibitors
TL;DR: Three ADA (adenosine deaminase) inhibitors, DHMPR, EHNA and deoxycoformycin (a transition state analog), were classified as readily reversible, semi-tight-binding and tight-binding inhibitors.