Chemistry and application of 4-oxo-4H-1-benzopyran-3-carboxaldehyde
TL;DR: The chemistry and application of the title aldehyde and some simple derivatives thereof are reviewed in this paper, where the authors propose a simple derivative of the aldehydes, which they call simple aldeheeds.
About: This article is published in Journal of Heterocyclic Chemistry.The article was published on 2008-11-01. It has received 42 citations till now. The article focuses on the topics: Benzopyran.
Citations
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TL;DR: In this article, the starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride.
38 citations
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TL;DR: A new mode of three-component reactions between isocyanoacetates, amines and 3-formylchromones is presented, which enables an efficient synthesis of polysubstituted pyrroles.
36 citations
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TL;DR: The first synthesis of 3-methoxalylchromone was described, where the reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO(2)Me substituent located at the α-position of the pyridine core.
Abstract: The first synthesis of 3-methoxalylchromone was described. The reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO2Me substituent located at the α-position of the pyridine core.
34 citations
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TL;DR: This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century with a focus on the synthesis of chromone-pyrazole dyads.
Abstract: Chromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacent-nitrogen-containing heterocycles, represent two important classes of biologically active compounds. Certain derivatives of these scaffolds play an important role in medicinal chemistry and have been extensively used as versatile building blocks in organic synthesis. In this context, we will discuss the most relevant advances on the chemistry that involves both chromone and pyrazole rings. The methods reviewed include the synthesis of chromone-pyrazole dyads, synthesis of chromone-pyrazole-fused compounds, and chromones as starting materials in the synthesis of 3(5)-(2-hydroxyaryl)pyrazoles, among others. This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century.
33 citations
Cites background from "Chemistry and application of 4-oxo-..."
...The reactivity of 3-formylchromone derivatives with a series of hydrazines has been studied in detail over the most recent years (for recent reviews see [103,104])....
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References
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TL;DR: On heating a mixture of 3-formylchromone 1, active methylene compound 2 or 3 and urea (4) in AcOH produces dihydropyrimidinones 10 or 11, whereas use of thiourea in place of urea produces 1,3-thiazine derivative 14 or 15 and the above reactions pass through the Knoevenagel condensate 5 or 6.
4 citations
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TL;DR: A comprehensive survey of the synthesis and chemistry of the title nitrile covering the literature published during 2005-2014 can be found in this paper, where a review article is designed to complement an earlier one (J. Heterocycl. Chem. 2005, 42, 1035-1042).
Abstract: The review article, primarily designed to complement an earlier one (J. Heterocycl. Chem. 2005, 42, 1035-1042), gives a comprehensive survey of the synthesis and chemistry of the title nitrile covering the literature published during 2005-2014.
3 citations
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TL;DR: The title dihydrofurans (3f, R1= H, Me, and Cl) as discussed by the authors is derived from the α-cyano-ester (1e) and diazomethane, which thermally rearrange to cyclopropanes (4f) in predominantly Z-isomeric form.
Abstract: The title dihydrofurans (3f, R1= H, Me, and Cl), prepared from the α-cyano-ester (1e) and diazomethane, thermally rearrange to the cyclopropanes (4f) in predominantly Z-isomeric form.
3 citations
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TL;DR: In this paper, the synthesis of hitherto unreported bischromone 6 has been accomplished and their reactions with methanol under neutral, acidic and basic condition are reported, but their results are limited.
3 citations