Chemistry and application of 4-oxo-4H-1-benzopyran-3-carboxaldehyde
TL;DR: The chemistry and application of the title aldehyde and some simple derivatives thereof are reviewed in this paper, where the authors propose a simple derivative of the aldehydes, which they call simple aldeheeds.
About: This article is published in Journal of Heterocyclic Chemistry.The article was published on 2008-11-01. It has received 42 citations till now. The article focuses on the topics: Benzopyran.
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71 citations
TL;DR: In this article, the starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride.
38 citations
TL;DR: A new mode of three-component reactions between isocyanoacetates, amines and 3-formylchromones is presented, which enables an efficient synthesis of polysubstituted pyrroles.
36 citations
TL;DR: The first synthesis of 3-methoxalylchromone was described, where the reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO(2)Me substituent located at the α-position of the pyridine core.
Abstract: The first synthesis of 3-methoxalylchromone was described. The reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO2Me substituent located at the α-position of the pyridine core.
34 citations
TL;DR: This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century with a focus on the synthesis of chromone-pyrazole dyads.
Abstract: Chromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacent-nitrogen-containing heterocycles, represent two important classes of biologically active compounds. Certain derivatives of these scaffolds play an important role in medicinal chemistry and have been extensively used as versatile building blocks in organic synthesis. In this context, we will discuss the most relevant advances on the chemistry that involves both chromone and pyrazole rings. The methods reviewed include the synthesis of chromone-pyrazole dyads, synthesis of chromone-pyrazole-fused compounds, and chromones as starting materials in the synthesis of 3(5)-(2-hydroxyaryl)pyrazoles, among others. This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century.
33 citations
Cites background from "Chemistry and application of 4-oxo-..."
...The reactivity of 3-formylchromone derivatives with a series of hydrazines has been studied in detail over the most recent years (for recent reviews see [103,104])....
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TL;DR: In this paper, a simple efficient and environment ecofriendly route has been developed for the synthesis of ylidenenitriles of======4-oxo-(4H)-1-benzopyran-3-carbaldehyde by the condensation of======ργαβδαβαββα βαβγα ββββγ βαγβαγ ββγβγγ βγαγγαα βγββ βγγ αβγδβααβ ββα αβ
44 citations
TL;DR: In this paper, the reaction of 6-aminopyrimidines 4 with 3-formylchromone under microwave irradiation in dry media and classical heating in absolute ethanol afforded in all cases the unexpected 6-hydroxy-6,9-dihydrobenzopyranopyrido[2,3-d ]pyrimidin-8-ones 6a − e (alternatively named, 6- hydroxy- 6,9dihdro-5-oxa-9,11,12-triazabenzo[ a
41 citations
TL;DR: K-10 Montmorillonite mediated condensation of aldehyde 1 with arylamine 2 affords chroman-2,4-dione 5 which gives tricoumarol 8 by acid hydrolysis, 4-arylamino-3-formylcoumarin 11 and 1-benzopyrano[4,3-b]quinoline 12 on heating with POCl3 as discussed by the authors.
41 citations
TL;DR: An efficient new route to the benzo[ b ]xanthone system has been developed and applied to the synthesis of several new derivatives as mentioned in this paper, such as benzo-3-carboxaldehydes.
40 citations
TL;DR: The title aldehyde 1 in the presence of ammonia gives the pyridine derivatives 9-11 respectively with acetylacetone, diethyl malonate and ethyl cyanoacetate, and the coumarinopyridines 25 and 26, respectively as discussed by the authors.
39 citations