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Chemistry and metabolism of lipids in the vertebrate retina
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This article is published in Progress in Lipid Research.The article was published on 1983-01-01. It has received 1013 citations till now. The article focuses on the topics: Lipid metabolism.read more
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A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
A. Kassoff,J. Kassoff,J. Buehler,M. Eglow,F. Kaufman,M. Mehu,S. Kieval,M. Mairs,B. Graig,A. Quattrocchi,David R. Jones,J. Locatelli,Alan J. Ruby,A Jr Capon,Bruce R. Garretson,Tarek S Hassan,Michael T. Trese,George A. Williams,V. Regan,P. Manatrey,P. Streasick,L. Szydlowski,F. McIver,C. Bridges,C. Stanley,K. Cumming,B. Lewis,Mary Zajechowski,R. R. Margherio,M. S. Cox,J. C. Werner,R. Falk,P. Siedlak,C. Neubert,Michael L. Klein,J. T. Stout,A. O'Malley,Andreas K. Lauer,Joseph E. Robertson,David J. Wilson,C. Beardsley,H. Anderson,P. Wallace,G. Smith,Shannon Howard,Richard F. Dreyer,C. Ma,R. G. Chenoweth,John Zilis,M. Johnson,Patrick B. Rice,H. Daniel,H. Crider,Stuart G Parker,K. Sherman,Daniel F. Martin,T M Sr Aaberg,P Jr Sternberg,Linda Curtis,B. Ju,James Gilman,B. Myles,S. Strittman,Christina Gentry,H. Yi,A Jr Capone,M. Lambert,Travis A. Meredith,T M Jr Aaberg,D. Saperstein,J. I. Lim,B. Stribling,D. Armiger,R. Swords,David H. Orth,T. P. Flood,J. Civantos,S. deBustros,Kirk H. Packo,Pauline T. Merrill,J. A. Cohen,Celeste Figliulo,Chris Morrison,D. A. Bryant,Don Doherty,M. McVicker,T. Drefcinski,J. M. Seddon,M. K. Pinnolis,N. Davis,I. Burton,T. Taitsel,David I. Walsh,J. Dubois-Moran,C. Callahan,Claudia Evans,K. K. Snow,D. A. Jones-Devonish,V. D. Crouse +98 more
TL;DR: People older than 55 years should have dilated eye examinations to determine their risk of developing advanced AMD and those with extensive intermediate size drusen, at least 1 large druse, noncentral geographic atrophy in 1 or both eyes, or advanced AMD or vision loss due to AMD in 1 eye should consider taking a supplement of antioxidants plus zinc.
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The Retinal Pigment Epithelium in Visual Function
TL;DR: This review summarizes the current knowledge of RPE functions and describes how failure of these functions causes loss of visual function.
Journal ArticleDOI
Drusen proteome analysis: An approach to the etiology of age-related macular degeneration
John W. Crabb,Masaru Miyagi,Xiaorong Gu,Karen G. Shadrach,K.A. West,Hirokazu Sakaguchi,Motohiro Kamei,Azeem Hasan,Lin Yan,Mary E. Rayborn,Robert G. Salomon,Joe G. Hollyfield +11 more
TL;DR: Data strongly support the hypothesis that oxidative injury contributes to the pathogenesis of AMD and suggest that oxidative protein modifications may have a critical role in drusen formation.
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Insights into the Function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in abcr Knockout Mice
TL;DR: The ocular phenotype in abcr knockout mice is characterized and data suggest that RmP functions as an outwardly directed flippase for N-retinylidene-PE, and ABCR-mediated retinal degeneration may result from "poisoning" of the RPE due to A2-E accumulation.
References
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Solubilization of membranes by detergents
Ari Helenius,Kai Simons +1 more
TL;DR: This review focuses on work that deals with the mechanisms of detergent action in membrane solubilization including properties of detergents model lipid systems and detergent-protein interactions; in addition a possible sequence of events when deterGents interact with biological membranes receives attention.
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CHROMATOGRAPHlC SEPARATION OF HUMAN BRAIN GANGLIOSIDES
TL;DR: Chromatographic methods for the quantitative isolation and separation of human brain gangliosides are described and it is shown that predominantly the gangLiosides have a common basic structure : N-acyl-sphingosine-glucose-Galactose-galactoseN-acetylgalactosamine-gal actose to which one or more molecules of N-acetelneuraininic acid are bound.
Journal ArticleDOI
Phospholipid methylation and biological signal transmission
Fusao Hirata,Julius Axelrod +1 more
TL;DR: The methylation of phospholipids is coupled to Ca2+ influx and the release of arachidonic acid, lysophosphatidylcholine, and prostaglandins, resulting in the generation of adenosine 3',5'-monophophate in many cell types, release of histamine in mast cells and basophils, mitogenesis in lymphocytes, and chemotaxis in neutrophils.