Chemistry of Amino Acids and Proteins
01 Jun 1941-Annual Review of Biochemistry (Annual Reviews 4139 El Camino Way, P.O. Box 10139, Palo Alto, CA 94303-0139, USA)-Vol. 10, Iss: 1, pp 91-124
About: This article is published in Annual Review of Biochemistry.The article was published on 1941-06-01. It has received 2 citations till now. The article focuses on the topics: Edman degradation & Amino acid.
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TL;DR: The chapter describes the advances that have been made in this branch of protein chemistry during the past 15 years and recommends methods for isolating every amino acid in a high state of purity and from all kinds of biological material.
Abstract: Publisher Summary This chapter discusses the problem of determining the nature and number of the component amino acid residues of proteins and related compounds. Many of the techniques for separating amino acids are also suitable for the much more difficult tasks of separating the peptides resulting from the partial hydrolysis of proteins; some of these techniques have in fact been developed with this as their primary aim. Studies of partial hydrolysis products are likely to be very fruitful for the detailed elucidation of protein structure. That reliable methods of amino acid analysis should be available is important also for agricultural, clinical, and nutritional work. In these disciplines, accuracy may often profitably be sacrificed in favor of speed and simplicity of manipulation. In connection with metabolic studies making use of isotopes it is desirable that methods be available for isolating every amino acid in a high state of purity and from all kinds of biological material. Special methods are also required for checking the purity of pure amino acids. The chapter describes the advances that have been made in this branch of protein chemistry during the past 15 years.
61 citations
01 Jan 1952
TL;DR: In this paper, Thomas Graham beobachtete namlich, das alle kristallisierbaren Stoffe in gelostem Zustand schnell diffundieren, wahrend Leim, Gummi, Eiweis und and other Stoffse, die man damals nicht in kristalisiertem ZUSTAND kannte, nur langsam oder gar nicht diffundiereren.
Abstract: Im Jahre 1861 glaubte Thomas Graham 1, das es moglich ware, alle chemischen Substanzen in zwei Gruppen einzuteilen: Kristalloide und Kolloide, entsprechend der Fahigkeit dieser Stoffe, in Losung durch eine Membran, z. B. Pergamentpapier, zu diffundieren oder nicht. Er beobachtete namlich, das alle kristallisierbaren Stoffe in gelostem Zustand schnell diffundieren, wahrend Leim, Gummi, Eiweis und andere Stoffe, die man damals nicht in kristallisiertem Zustande kannte, nur langsam oder gar nicht diffundieren. Damit hat Graham den Grundstein zu einer neuen Lehre, der Kolloidchemie, gelegt.
5 citations