Chemotaxis in cancer
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Cites background from "Chemotaxis in cancer"
...Because of their pleiotropic effects, promigratory conditioning of the tumor-associated tissue increases: (1) the invasion and dissemination of tumor cells; (2) the motility and activity of stromal cells, including fibroblasts and macrophages; (3) the recruitment and transendothelial migration of circulating leukocytes and precursor cells into the tumor stroma; and (4) the mobilization of bone marrow-derived cells into the circulation through systemic growth factor effects in other organs, including the bone marrow (Orimo et al., 2005; Padua and Massagué, 2009; Roussos et al., 2011; Zlotnik et al., 2011)....
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...…and precursor cells into the tumor stroma; and (4) the mobilization of bone marrow-derived cells into the circulation through systemic growth factor effects in other organs, including the bone marrow (Orimo et al., 2005; Padua and Massagué, 2009; Roussos et al., 2011; Zlotnik et al., 2011)....
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Cites background from "Chemotaxis in cancer"
...Cell-cell communication and chemotaxis (5) are key to this process and can occur via paracrine signals and/or direct contact between different cell types during tumor cell invasion (6) and metastatic colonization (7)....
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References
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"Chemotaxis in cancer" refers background in this paper
...Tumour cells undergoing epithelial-to-mesenchymal transition (EMT), which is apparent in 10–40% of carcinoma...
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"Chemotaxis in cancer" refers background in this paper
...T Reg cells express the chemokine receptor CCR4 and can be attracted to ovarian cancer cells by the tumour cell- and macrophage-derived chemokine ligand CCL22 (Ref...
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4,244 citations