scispace - formally typeset
Search or ask a question
Journal ArticleDOI

Chikungunya virus, southeastern France.

TL;DR: Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the chikungunya virus in Europe.
Abstract: In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present. Sequence analysis of the viral genomes of imported and autochthonous isolates indicated new features for the potential emergence and spread of the virus in Europe.

Content maybe subject to copyright    Report

Citations
More filters
Journal ArticleDOI
30 Jun 2015-eLife
TL;DR: In this paper, the authors compile the largest contemporary database for both species and pair it with relevant environmental variables predicting their global distribution, showing Aedes distributions to be the widest ever recorded; now extensive in all continents, including North America and Europe.
Abstract: Dengue and chikungunya are increasing global public health concerns due to their rapid geographical spread and increasing disease burden. Knowledge of the contemporary distribution of their shared vectors, Aedes aegypti and Aedes albopictus remains incomplete and is complicated by an ongoing range expansion fuelled by increased global trade and travel. Mapping the global distribution of these vectors and the geographical determinants of their ranges is essential for public health planning. Here we compile the largest contemporary database for both species and pair it with relevant environmental variables predicting their global distribution. We show Aedes distributions to be the widest ever recorded; now extensive in all continents, including North America and Europe. These maps will help define the spatial limits of current autochthonous transmission of dengue and chikungunya viruses. It is only with this kind of rigorous entomological baseline that we can hope to project future health impacts of these viruses.

1,416 citations

Journal Article
TL;DR: This work compile the largest contemporary database for both species and pair it with relevant environmental variables predicting their global distribution, showing Aedes distributions to be the widest ever recorded; now extensive in all continents, including North America and Europe.

1,002 citations


Cites background from "Chikungunya virus, southeastern Fra..."

  • ...…in 2007 (205 infections) (Rezza et al., 2007), and France in 2010 and 2014 (2 and 11 locally transmitted cases, respectively) (La Ruche et al., 2010; Grandadam et al., 2011; Paty et al., 2014) as well as its recent invasion into the Americas with over 1 million cases recorded to date (Cauchemez…...

    [...]

  • ..., 2007), and France in 2010 and 2014 (2 and 11 locally transmitted cases, respectively) (La Ruche et al., 2010; Grandadam et al., 2011; Paty et al., 2014) as well as its recent invasion into the Americas with over 1 million cases recorded to date (Cauchemez et al....

    [...]

Journal ArticleDOI
TL;DR: The clinical and laboratory features of two mothers and their newborns who had ZikAV infection as confirmed by ZIKAV RT-PCR performed on serum collected within four days post-delivery in date are described.
Abstract: A Zika virus (ZIKAV) outbreak started in October 2013 in French Polynesia, South Pacific. We describe here the clinical and laboratory features of two mothers and their newborns who had ZIKAV infection as confirmed by ZIKAV RT-PCR performed on serum collected within four days post-delivery in date. The infants' infection most probably occurred by transplacental transmission or during delivery. Attention should be paid to ZIKAV-infected pregnant women and their newborns, as data on the impact on them are limited. .

791 citations

Journal ArticleDOI
TL;DR: Current understanding of all exotic aedine species in Europe is reviewed, highlighting the known import pathways, biotic and abiotic constraints for establishment, control strategies, and public health significance, and encourages Europe-wide surveillance for invasive mosquitoes.
Abstract: There has been growing interest in Europe in recent years in the establishment and spread of invasive mosquitoes, notably the incursion of Aedes albopictus through the international trade in used tires and lucky bamboo, with onward spread within Europe through ground transport. More recently, five other non-European aedine mosquito species have been found in Europe, and in some cases populations have established locally and are spreading. Concerns have been raised about the involvement of these mosquito species in transmission cycles of pathogens of public health importance, and these concerns were borne out following the outbreak of chikungunya fever in Italy in 2007, and subsequent autochthonous cases of dengue fever in France and Croatia in 2010. This article reviews current understanding of all exotic (five introduced invasive and one intercepted) aedine species in Europe, highlighting the known import pathways, biotic and abiotic constraints for establishment, control strategies, and public health significance, and encourages Europe-wide surveillance for invasive mosquitoes.

561 citations


Additional excerpts

  • ...Of the invasive mosquito species discovered in Europe, the Asian Tiger mosquito, Aedes (Stegomyia) albopictus, probably presents the major threat to public health in Europe....

    [...]

  • ...Key Words: Aedes—Europe—Invasive mosquitoes—Vector-borne disease....

    [...]

  • ...It is found throughout tropical and subtropical regions of the Americas, Africa, and Asia, as well as the southeastern U.S., the Indian Ocean islands, and northern Australia (Soumahoro et al. 2010)....

    [...]

  • ...A. aegypti was also responsible for large epidemics of dengue in Greece in 1927–1928 (Rosen 1986), and outbreaks of CHIKV have occurred more recently in Kenya, India, other parts of Asia, and the Comoros Islands (Gould and Higgs 2009)....

    [...]

  • ...In 2010, two autochthonous CHIKV cases were also reported in France following reports of an imported case from Asia (Grandadam et al. 2011)....

    [...]

Journal ArticleDOI
TL;DR: A comprehensive review of chikungunya fever and CHIKV, including clinical data, epidemiological reports, therapeutic aspects and data relating to animal models for in vivo laboratory studies, including Supplementary Tables of all WHO outbreak bulletins, ProMED Mail alerts, viral sequences available on GenBank, and PubMed reports of clinical cases and seroprevalence studies are provided.

420 citations


Cites background from "Chikungunya virus, southeastern Fra..."

  • ...More recently, in September 2010, an autochthonous transmission of CHIKV was recorded in southeastern France with two confirmed cases (Gould et al., 2010; Grandadam et al., 2011)....

    [...]

References
More filters
Journal ArticleDOI
TL;DR: In this article, an outbreak of chikungunya virus (CHIKV) was reported in Italy, where the primary source of infection and modes of transmission were identified and an active surveillance system was also implemented.

1,373 citations

Journal ArticleDOI
TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
Abstract: Chikungunya virus (CHIKV) is an emerging arbovirus associated with several recent large-scale epidemics. The 2005–2006 epidemic on Reunion island that resulted in approximately 266,000 human cases was associated with a strain of CHIKV with a mutation in the envelope protein gene (E1-A226V). To test the hypothesis that this mutation in the epidemic CHIKV (strain LR2006 OPY1) might influence fitness for different vector species, viral infectivity, dissemination, and transmission of CHIKV were compared in Aedes albopictus, the species implicated in the epidemic, and the recognized vector Ae. aegypti. Using viral infectious clones of the Reunion strain and a West African strain of CHIKV, into which either the E1–226 A or V mutation was engineered, we demonstrated that the E1-A226V mutation was directly responsible for a significant increase in CHIKV infectivity for Ae. albopictus, and led to more efficient viral dissemination into mosquito secondary organs and transmission to suckling mice. This mutation caused a marginal decrease in CHIKV Ae. aegypti midgut infectivity, had no effect on viral dissemination, and was associated with a slight increase in transmission by Ae. aegypti to suckling mice in competition experiments. The effect of the E1-A226V mutation on cholesterol dependence of CHIKV was also analyzed, revealing an association between cholesterol dependence and increased fitness of CHIKV in Ae. albopictus. Our observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector. This has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area. Due to the widespread distribution of Ae. albopictus, this mutation increases the potential for CHIKV to permanently extend its range into Europe and the Americas.

1,303 citations

Journal ArticleDOI
TL;DR: Viruses such as dengue (DENV) and chikungunya (CHIKV) that have lost the requirement for enzootic amplification now produce extensive epidemics in tropical urban centers, and climate warming could facilitate the expansion of the distributions of many arboviruses.

1,250 citations

Journal ArticleDOI
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
Abstract: A chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Reunion Island, this alphavirus has already infected about one-third of the human population. The main clinical symptom of the disease is a painful and invalidating poly-arthralgia. Besides the arthralgic form, 123 patients with a confirmed chikungunya infection have developed severe clinical signs, i.e., neurological signs or fulminant hepatitis.

1,085 citations

Related Papers (5)