Chitosan-based scaffolds for bone tissue engineering
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TLDR
This review discusses the fundamentals of bone tissue engineering and the unique properties of chitosan as a scaffolding material to treat bone defects for hard tissue regeneration, and discusses the influence of material preparation and addition of polymeric or ceramic components or biomolecules on chitOSan scaffold properties such as mechanical strength, structural integrity, and functional bone regeneration.Abstract:
Bone defects requiring grafts to promote healing are frequently occurring and costly problems in health care. Chitosan, a biodegradable, naturally occurring polymer, has drawn considerable attention in recent years as a scaffolding material in tissue engineering and regenerative medicine. Chitosan is especially attractive as a bone scaffold material because it supports the attachment and proliferation of osteoblast cells as well as formation of mineralized bone matrix. In this review, we discuss the fundamentals of bone tissue engineering and the unique properties of chitosan as a scaffolding material to treat bone defects for hard tissue regeneration. We present common methods for fabrication and characterization of chitosan scaffolds, and discuss the influence of material preparation and addition of polymeric or ceramic components or biomolecules on chitosan scaffold properties such as mechanical strength, structural integrity, and functional bone regeneration. Finally, we highlight recent advances in the development of chitosan-based scaffolds with enhanced bone regeneration capability.read more
Citations
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3D bioactive composite scaffolds for bone tissue engineering.
Gareth Turnbull,Jon Clarke,Frederic Picard,Frederic Picard,Philip Riches,Luanluan Jia,Fengxuan Han,Bin Li,Wenmiao Shu +8 more
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Saad M. Ahsan,Mathai Thomas,Kranthi K. Reddy,Sujata Gopal Sooraparaju,Amit Asthana,Ira Bhatnagar +5 more
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Chitin and Chitosan: Production and Application of Versatile Biomedical Nanomaterials.
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A Novel Fabrication Method of Macroporous Biodegradable Polymer Scaffolds Using Gas Foaming Salt as Porogen Additive
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References
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