Book ChapterDOI
Cholinesterases: Tissue and Cellular Distribution of Molecular Forms and Their Physiological Regulation
J.-P. Toutant,Jean Massoulié +1 more
- pp 225-265
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TLDR
It is shown that the two enzymes present globular forms which exist as non-hydrophobic as well as amphiphilic molecules, and asymmetric, collagen-tailed molecules, which may be further subdivided according to the binding of lectins or according to their electrophoretic migrations in nondenaturing electrophoresis.Abstract:
In Chapter 8 a we have described the molecular structure and the interactions of the multiple molecular forms of acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BuChE, EC 3.1.1.8) in vertebrates. We show there that the two enzymes present globular forms (G1 G2, G4) which exist as non-hydrophobic as well as amphiphilic molecules, and asymmetric, collagen-tailed molecules (A4, A8, A12). These molecular forms may be further subdivided according to the binding of lectins or according to their electrophoretic migrations in nondenaturing electrophoresis.read more
Citations
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Journal ArticleDOI
Molecular and cellular biology of cholinesterases
TL;DR: In this article, the authors propose a method to identify the root cause of a problem.Abbreviations: [2]... ].., [3]
Journal ArticleDOI
Synaptic structure and development: the neuromuscular junction.
Zach W. Hall,Joshua R. Sanes +1 more
TL;DR: This review describes the cytological and molecular architecture of the neuromuscular junction, making three main points: that chemical synapses are designed for rapid, focal transmission of information; that this task is performed by highly specialized preand postsynaptic domains that lie in precise juxtaposition across the synaptic cleft; and that many of the components forming these domains have now been isolated and characterized.
Journal ArticleDOI
Insect acetylcholinesterase: catalytic properties, tissue distribution and molecular forms.
TL;DR: In this paper, the authors propose a method to identify the root cause of a problem.Abbreviations: [2]... ].., [3]
Journal ArticleDOI
The Mammalian Gene of Acetylcholinesterase-associated Collagen
TL;DR: The cloning of a rat AChE-associated collagen subunit, Q, is reported and it is found that the same ColQ subunits are incorporated, in vivo, in asymmetric forms of both A ChE and butyrylcholinesterase.
Journal ArticleDOI
Genetic Analysis of Collagen Q: Roles in Acetylcholinesterase and Butyrylcholinesterase Assembly and in Synaptic Structure and Function
TL;DR: In this paper, the role of the collagenous subunit Q (ColQ) and its role in the assembly of AChE and butyrylcholinesterase was investigated.
References
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Journal ArticleDOI
Inositol trisphosphate, a novel second messenger in cellular signal transduction.
TL;DR: Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.
Journal ArticleDOI
The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat
TL;DR: An atlas of the distribution of cholinergic cell bodies, fibers, and terminals, as well as cholinoceptive cells, in the central nervous system of the cat (excluding the cerebellum) is presented from results obtained in immunohistochemical work on choline acetyltransferase.
Journal ArticleDOI
The Molecular Forms of Cholinesterase and Acetylcholinesterase in Vertebrates
J Massoulié,S Bon +1 more
TL;DR: The mechanism of cholinergic neurotransmission requires the rapid inac tivation of acetylcholine, which exists in all classes of vertebrates and is characterized in horse serum by Stedman et al (1932), who called it choli nesterase.
Book
The biology of cholinesterases
TL;DR: The biology of cholinesterases is studied in detail in two separate studies at the University of California, Davis.
Related Papers (5)
The Molecular Forms of Cholinesterase and Acetylcholinesterase in Vertebrates
J Massoulié,S Bon +1 more