Chondroitinase ABC promotes functional recovery after spinal cord injury
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Cites background from "Chondroitinase ABC promotes functio..."
...Intrathecal application of chondroitinase to animals with bilateral dorsal column lesions resulted in degradation of CSPG at the lesion site, and allowed both ascending sensory and descending motor axon regeneration through, and perhaps even slightly past, the lesio...
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Cites background from "Chondroitinase ABC promotes functio..."
...Others have shown that chABC can be used in vivo and in vitro to degrade inhibitory proteoglycan substrates and promote axon sprouting and regeneration (Bradbury et al., 2002; Steinmetz et al., 2005)....
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Cites background from "Chondroitinase ABC promotes functio..."
...For instance, reactive astrocytes can inhibit axon regeneration after CNS injury (McKeon et al., 1991; Bradbury et al., 2002; Fitch and Silver, 2008; Alilain et al., 2011) and can produce proinflammatory cytokines that exacerbate spinal cord injuries (Brambilla et al....
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"Chondroitinase ABC promotes functio..." refers background in this paper
...At sites of CNS injury, a glial scar develops, containing extracellular matrix molecules including chondroitin sulphate proteoglycans (CSPGs)...
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