Chromatin dynamics during spermiogenesis.
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261 citations
Cites background from "Chromatin dynamics during spermioge..."
...However, 1–10% of histones are retained in mammals, depending on species [106]....
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225 citations
Cites background from "Chromatin dynamics during spermioge..."
...During the post-meiotic stages of spermatogenesis, haploid spermatids undergo extensive morphological changes including a striking chromatin reorganization and compaction [102]....
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217 citations
Cites background from "Chromatin dynamics during spermioge..."
...DNA double-strand breaks (DSBs) are endogenously induced during spermatogenesis; first during meiosis, to facilitate the formation of meiotic crossovers, and second during spermiogenesis, when the chromatin of the haploid round spermatids is compacted by the replacement of histones by protamines [8,9]....
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213 citations
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...Importantly, it has been reported that the BRDT protein co-localized with acetylated H4 chromatin in elongating spermatids (Shang et al. 2007), although other studies found that BRDT protein is either not detected in elongating spermatids or only partially overlap with acetylated histone (Shang et al. 2007, Berkovits & Wolgemuth 2011, Dhar et al. 2012)....
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...In support of the functional role of BRDT in vivo, a bromodomain-specific small-molecule inhibitor, JQ1, which specifically binds to the acetyl-lysine binding pocket, induced spermatogenic deficiency when applied to mice (Matzuk et al. 2012)....
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...Distinct from somatic cells, the majority of histone proteins, ~99% of histones in mice and ~90% in humans, will be first replaced by transition proteins and finally by the protamines during the late stage of haploid spermatid development (Rathke et al. 2014, Venkatesh & Workman 2015)....
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...1) (Rathke et al. 2014)....
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...…not only those common histone variants, posttranslational histone modifications, and chromatin remodelers that are found in somatic cells, but also many testis-specific factors, such as testis-specific histone variants (TH2B, H1T, etc.) and BRDT (Rathke et al. 2014, Venkatesh & Workman 2015)....
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References
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"Chromatin dynamics during spermioge..." refers background in this paper
...In mammals, the number of stages that can be observed varies among species [26]....
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1,395 citations
"Chromatin dynamics during spermioge..." refers background in this paper
...In addition, a wave of hypercrotonylation accompanies spermatid elongation [161], and thus, this modification...
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...fication of 67 novel histone modifications [161] indicates that we have just scratched the surface in trying to unravel the histone...
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1,224 citations