Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
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...This lesion pattern is consistent with chromoanagenesis (25), and indicates a punctuated evolution pattern where multiple oncogenic events may occur simultaneously (26)....
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Cites background from "Chromothripsis and beyond: rapid ge..."
..., 2016; Sima and Gilbert, 2014), including those that may arise through a single catastrophic event (Baca et al., 2013; Zhang et al., 2013)....
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...Examples include chromothripsis, in which amassive rearrangement was acquired in a single event, and chromoplexy, which involves coordinate and simultaneous rearrangements of multiple chromosomes (Zhang et al., 2013)....
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...…stark contrast to substitution mutations, which are predominant in heterochromatin, rearrangements are enriched in early replicating regions (Morganella et al., 2016; Sima and Gilbert, 2014), including those that may arise through a single catastrophic event (Baca et al., 2013; Zhang et al., 2013)....
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References
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"Chromothripsis and beyond: rapid ge..." refers background in this paper
...Genome instability is not only a hallmark but also an enabling characteristic of cancer (Negrini et al. 2010; Hanahan and Weinberg 2011; Gordon et al. 2012)....
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...By chance, these somatic alterations in the genome will hit cancer genes—disrupting tumor suppressors or activating proto-oncogenes—affecting cells and causing their progeny to gradually accumulate the necessary ‘‘hallmarks of cancer’’ (Hanahan and Weinberg 2011)....
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"Chromothripsis and beyond: rapid ge..." refers background in this paper
...Similarly, localized regions of hypermutation (‘‘kataegis’’) that often occurred at the site of somatic rearrangements were discovered in breast cancer genomes (Nik-Zainal et al. 2012; Alexandrov et al. 2013)....
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7,180 citations
"Chromothripsis and beyond: rapid ge..." refers background in this paper
...…for the abnormalities of chromoanasynthesis: There is evidence that breakpoint ends of copy number abnormalities tend to be in physical proximity (Lieberman-Aiden et al. 2009; De and Michor 2011; Fudenberg et al. 2011); hence, different template-switching events could have occurred in loosely…...
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"Chromothripsis and beyond: rapid ge..." refers background in this paper
...The evolution of a normal cell to a cancer cell is generally thought of as a sequential accumulation of many independent lesions to the genome (Nowell 1976; Greaves and Maley 2012; Yates and Campbell 2012)....
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