Journal ArticleDOI
Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning.
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TLDR
The introduction and evaluation of agents possessing a specificity of pharmacological action will undoubtedly aid psychotherapeutic research and the knowledge that peptides and 'classical' neurotransmitters can co-exist in the same neurone will undoubtedly generate studies of the significance and importance of the co-transmitter function of peptides in the mechanisms of action of antidepressant therapies.About:
This article is published in Pharmacology & Therapeutics.The article was published on 1983-01-01. It has received 156 citations till now. The article focuses on the topics: Antidepressant & Mechanism of action.read more
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Neurobiological similarities in depression and drug dependence : A self-medication hypothesis
TL;DR: It is concluded that drug dependence and depression may be associated with alterations in some of the same neurotransmitter systems and, in particular, with alterations of neurotransmitter function in limbic-related brain structures, and may be linked by some shared neurobiology.
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Comparison of pramipexole, fluoxetine, and placebo in patients with major depression.
TL;DR: Results indicated that by endpoint (week 8), patients receiving pramipexole at the 1.0 mg per day dose had significant improvement over baseline compared to the placebo group by measure of the HAM‐D, MADRS, and CGI‐SI.
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How do antidepressants work? New perspectives for refining future treatment approaches
TL;DR: The ways in which monoamine neurotransmitter-based and neural plasticity theories reflect different or complementary approaches to antidepressant drug action are discussed, and how they might be integrated to offer novel solutions for people with depression are discussed.
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Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin.
TL;DR: Female rats were less affected by a single restraint but failed to adapt to the repeated stress procedure and did not exhibit enhanced sensitivity to 5-methoxy-N,N-dimethyltryptamine.
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Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression.
TL;DR: The results suggest that 5-HT1A agonists may have rapid antidepressant properties and that vehicle-treated restrained rats showed reduced locomotor activity and increased defaecation in an open field test the day after the end of restraint.
References
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The catecholamine hypothesis of affective disorders: a review of supporting evidence
TL;DR: The "catecholamine hypothesis of affective disorders" as discussed by the authors suggests that depression is associated with an absolute or relative decrease in catecholamines, particularly norepinephrine, available at central adrenergic receptor sites.
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The role of hormone receptors and GTP-regulatory proteins in membrane transduction
TL;DR: Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with G TP, and this theory may apply generally to membrane signal transduction involving surface receptors.
Journal Article
Presynaptic regulation of the release of catecholamines.
TL;DR: Evidence has accumulated in favour of the view that, in addition to the classical postsynaptic adrenoceptors that mediate the responses of the effector organ, there are also receptors located on the noradrenergic nerve terminals that appear to be involved in the modulation of the release of dopamine and of epinephrine in the central nervous system.
Journal Article
Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
TL;DR: It is proposed that [3H]5-HT and[3H]-spiroperidol label distinct populations of serotonin receptors in rat brain, designated 5-HT1 and 5- HT2 receptors, respectively.
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The biochemistry of affective disorders.
TL;DR: The weight of evidence suggests that biochemical changes are most important in the aetiology of affective disorders, and that psychological and environmental events may precipitate and maintain the biochemical events which in turn lead to the affective disorder.