Chronic systemic pesticide exposure reproduces features of Parkinson's disease
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...This model has since been refined in laboratory animals, in which chronic infusion of rotenon...
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...…exerts a more widespreadPD. neurotoxicity than originally proposed, challenging theParaquat concept that dopaminergic neurons display preferentialThe herbicide paraquat (N,N -dimethyl-4-4 -bipiridisensitivity to complex I inhibition (Betarbet et al., 2000).nium) also induces a toxic model of PD....
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...…et al., 1992; Varasto rats produces selective degeneration of nigrostriatal tet et al., 1994); this regional pattern is also found in dopaminergic neurons accompanied by -synuclein-posi- MPTP-treated mice (Seniuk et al., 1990; Muthane et al., tive LB-like inclusions (Betarbet et al., 2000)....
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...Chronic infusion of rotenone does produce intraneuronal -synuclein-containing proteinacious aggregates (Betarbet et al., 2000), consistent with the possibility that the speed of intoxication may influence the subsequent neuropathologic features....
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...As noted above, In addition, the use of rotenone in rodents is technicallyparaquat shows structural similarity to MPP (Figure 3) challenging (Betarbet et al., 2000)....
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"Chronic systemic pesticide exposure..." refers background in this paper
...Rare cases of familial PD have been linked to mutations in α-synuclein or parki...
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4,705 citations
"Chronic systemic pesticide exposure..." refers background in this paper
...After the pro-toxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was reported to produce in humans an acute parkinsonian syndrome that is virtually indistinguishable from idiopathic P...
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