CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth
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Cites background from "CircSETD3 (Hsa_circ_0000567) acts a..."
...Based on adequate studies on the characteristics of circRNA, an increasing number of studies have focused on its regulatory function [59, 60] (Table 1)....
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"CircSETD3 (Hsa_circ_0000567) acts a..." refers background in this paper
...CircRNAs tend to be highly expressed in the cytoplasm of eukaryotic cells [12, 13]....
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...Since the report that circRNA can act as a “super sponge” for microRNA (miRNA) [13, 14], other studies have revealed that circRNAs broadly participate in the initiation and progression of various diseases, especially in malignant tumours, such as oesophageal squamous cell carcinoma (ciRS-7, circ-ITCH) [16, 17], gastric cancer (circPVT1, circLARP4) [18, 19], colorectal cancer (circITGA7, circCCDC66) [20, 21], and HCC (circMTO1, cSMARCA5) [22, 23]....
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...Since the demonstration of the stable expression of numerous circRNAs in eukaryocytes and the fact that some of them possess strong miRNA-binding capability [13, 14], interest in the role of circRNAs in a variety of diseases has risen....
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5,885 citations
"CircSETD3 (Hsa_circ_0000567) acts a..." refers background in this paper
...CircRNAs are stable, abundant, conserved and are usually expressed in particular tissues or at a specific developmental stage [14, 15]....
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...Previous studies have reported that circRNAs arising from exonic regions typically reside in the cytoplasm and some may serve as miRNA sponges [14]....
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...Since the report that circRNA can act as a “super sponge” for microRNA (miRNA) [13, 14], other studies have revealed that circRNAs broadly participate in the initiation and progression of various diseases, especially in malignant tumours, such as oesophageal squamous cell carcinoma (ciRS-7, circ-ITCH) [16, 17], gastric cancer (circPVT1, circLARP4) [18, 19], colorectal cancer (circITGA7, circCCDC66) [20, 21], and HCC (circMTO1, cSMARCA5) [22, 23]....
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...Since the demonstration of the stable expression of numerous circRNAs in eukaryocytes and the fact that some of them possess strong miRNA-binding capability [13, 14], interest in the role of circRNAs in a variety of diseases has risen....
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