Journal ArticleDOI
Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis
Binghong Chen,Mengying Wang,Renhua Huang,Keman Liao,Tianwei Wang,Renhao Yang,Wenrui Zhang,Zhonggang Shi,Li Ren,Qi Lv,Chunhui Ma,Yingying Lin,Yongming Qiu +12 more
Reads0
Chats0
TLDR
In this paper, the authors found that circLGMN was the most abundantly expressed circRNA derived from Legumain and showed that LGMN overexpression promoted GBM cell proliferation and enhanced cell invasion.About:
This article is published in Cancer Letters.The article was published on 2021-09-25. It has received 18 citations till now. The article focuses on the topics: Tumor progression.read more
Citations
More filters
Journal ArticleDOI
LncRNAs and CircRNAs in cancer
TL;DR: A review of the biological functions and important clinical therapeutic implications of lnRNAs and circRNAs in neuroblastoma focuses on providing rationale and relevant references for novel biomarkers for neuroblastomas diagnosis, prognosis, and treatment.
Journal ArticleDOI
Research Progress of circRNAs in Glioblastoma
Xu Guo,Haozhe Piao +1 more
TL;DR: The specific expression of circRNAs in GBM has shown their potential as new biomarkers for GBM cell proliferation, apoptosis, migration and invasion, which provides new ideas for Glioblastoma treatment.
Journal ArticleDOI
Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.
Mengying Wang,Binghong Chen,Wen-Rui Zhang,Fengchen Zhang,Yongming Qiu,Yingying Lin,Shaofeng Yang +6 more
TL;DR: Zhang et al. as mentioned in this paper showed that the dematin actin-binding protein (DMTN) inhibited GBM proliferation and invasion by affecting cell cycle regulation and actin remodeling, respectively.
Journal ArticleDOI
Research Progress on Circular RNA in Glioma.
TL;DR: In this article, a review of the biogenesis, metabolism, functions and properties of circRNA as a potential biomarker for gliomas is presented, where the authors elaborate the expression characteristics, interaction between circRNA and other molecules, and identify new targets for early diagnosis and treatment of glioma.
Journal ArticleDOI
Role of Circular RNA in Brain Tumor Development
TL;DR: Several mechanisms were examined in detail, including PI3K/Akt/mTOR signaling, Wnt/-catenin signaling, angiogenic processes, and metastatic pathways, in order to provide a comprehensive knowledge of the involvement of circRNAs in the pathophysiology of MB and GBM.
References
More filters
Journal ArticleDOI
CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.
Quinn T. Ostrom,Haley Gittleman,Peter Liao,Chaturia Rouse,Yanwen Chen,Jacqueline Dowling,Yingli Wolinsky,Carol Kruchko,Jill S. Barnholtz-Sloan +8 more
TL;DR: The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the US.
Journal ArticleDOI
Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
Journal ArticleDOI
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data
TL;DR: This study developed starBase v2.0, which has been updated to provide the most comprehensive CLIP-Seq experimentally supported miRNA-mRNA and mi RNA-lncRNA interaction networks to date, and developed miRFunction and ceRNAFunction web servers to predict the function of miRNAs and other ncRNAs from themiRNA-mediated regulatory networks.
Journal ArticleDOI
The multilayered complexity of ceRNA crosstalk and competition
TL;DR: Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.
Journal ArticleDOI
The biogenesis, biology and characterization of circular RNAs.
Lasse Sommer Kristensen,Maria S. Andersen,Lotte V. W. Stagsted,Karoline K. Ebbesen,Thomas B. Hansen,Jørgen Kjems +5 more
TL;DR: Advances in high-throughput RNA sequencing and circRNA-specific computational tools have driven the development of state-of-the-art approaches for their identification, and novel approaches to functional characterization are emerging.