Circular RNAs are abundant, conserved, and associated with ALU repeats
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...As previously reported for other circRNAs (Jeck et al., 2013;Memczak et al., 2013), circMbl is unusually stable and its level did not decrease in theassayed time frame....
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...…asmiRNA sponges (Hansen et al., 2013; Memczak et al., 2013), but no function is known for the other thousands of circRNAs that have been found across the animal kingdom (Danan et al., 2012; Hansen et al., 2013; Jeck et al., 2013; Memczak et al., 2013; Salzman et al., 2012, 2013; Wang et al., 2014)....
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..., 2013), but no function is known for the other thousands of circRNAs that have been found across the animal kingdom (Danan et al., 2012; Hansen et al., 2013; Jeck et al., 2013; Memczak et al., 2013; Salzman et al., 2012, 2013; Wang et al., 2014)....
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...Moreover, these introns in humans are enriched in ALU repeats (Jeck et al., 2013), and in the single case of the Sry circRNA it has been shown that intronic elements can be sufficient to promote circularization (Dubin et al....
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...This is likely due to the fact that circRNAs are flanked by considerably longer introns (see Jeck et al., 2013 and Figure S3B), which are less efficiently spliced cotranscriptionally (Khodor et al., 2012)....
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"Circular RNAs are abundant, conserv..." refers background in this paper
...Though the bulk of these noncoding RNAs consist of the rRNA and tRNA apparatus required for translation, it has been increasingly appreciated that noncoding products comprise a diverse set of species relevant in core biological processes and disease (Esteller 2011)....
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