Circulating branched‐chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents
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Cites background or result from "Circulating branched‐chain amino ac..."
...…a positive correlation between BCAAs, BMI, andHOMAIR (Newbern et al., 2014; Perng et al., 2014), and another showed an association with obesity (McCormack et al., 2013), but still others found no significant differences in BCAA levels in normal weight compared to obese adolescents (Wahl et…...
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...However, in a group of 17 pre- or early-pubertal children (age 8–13 years), baseline BCAA levels were found to be associated with HOMA-IR measured 18 months later, suggesting that, as in adults, BCAA levels may be predictive of future disease risk in adolescent subjects (McCormack et al., 2013)....
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...an association with obesity (McCormack et al., 2013), but still others found no significant differences in BCAA levels in normal weight compared to obese adolescents (Wahl et al....
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Cites background from "Circulating branched‐chain amino ac..."
...also reported that elevations in BCAAs concentrations are significantly related to obesity in children and adolescents, and may be independently predict future IR [96]....
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358 citations
Cites background from "Circulating branched‐chain amino ac..."
...Recently, the relationship between metabolomics and obesity (insulinresistant) was revealed by a series of studies [114]....
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References
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"Circulating branched‐chain amino ac..." refers methods in this paper
...99), using identical linear scales, without systemic differences in the results of the assays by Bland–Altman analysis (21)....
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"Circulating branched‐chain amino ac..." refers methods in this paper
...The primary outcome variable in the longitudinal cohort was future insulin resistance, as estimated by the homeostasis model assessment for insulin resistance (HOMA-IR) (17)....
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"Circulating branched‐chain amino ac..." refers methods in this paper
...This index is defined as 10 000/square root of [fasting glucose ¥ fasting insulin] ¥ [mean glucose ¥ mean insulin] during the OGTT and is associated with the rate of glucose disposal as assessed by euglycemic clamp (19)....
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