Cisplatin in cancer therapy: molecular mechanisms of action
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Cites background from "Cisplatin in cancer therapy: molecu..."
...Again p53 actives PUMA [72], PIDD [73] and MAPK protein family [12] which are responsible for cell apoptosis....
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...which makes higher sensitivity to cisplatin [12]....
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...is used for wide range of solid cancers such as testicular, ovarian, bladder, lung, cervical, head and neck cancer, gastric cancer and some other cancers [11,12,285]....
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...They can react with a number of nucleophiles like sulfhydryl groups of protein and nitrogen donor atoms of nucleic acids etc [12] because water is better leaving group than chloride [49]....
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...p53 causes apoptosis directly by different mechanisms like: Degradation of FLIP (flice-like inhibitory protein), direct binding and counteracting the antiapoptotic function of Bcl-xL (B-cell lymphoma-extra-large), over expression of PTEN (phosphatase and tensin homolog) [12,71]....
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"Cisplatin in cancer therapy: molecu..." refers background in this paper
...Mitogen activated protein kinases are a family of structurally related serine/threonine protein kinases that coordinate various extra cellular signals to regulate cell growth and survival (Chang and Karin, 2001;Johnson and Lapadat, 2002;Marshall, 1995)....
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...…and mitogen-activated protein kinase (MAPK) Mitogen activated protein kinases are a family of structurally related serine/threonine protein kinases that coordinate various extra cellular signals to regulate cell growth and survival (Chang and Karin, 2001;Johnson and Lapadat, 2002;Marshall, 1995)....
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