Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
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...Finally, the intersection between GPCR ignaling and metabolism was recently strengthen by nother fascinating observation that the citric acid inermediates succinate and α-ketoglutarate are actually he endogenous ligands for two separate mammalian rphan GPCR (He et al., 2004)....
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...This provocative result uggests a potentially important connection between etabolism, stress resistance, and GPCR signaling. onetheless, it also raises a number of important unanwered questions including how a presumed mitohondrial protein can function as a ligand for a cell surace receptor....
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...The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila....
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...These reults suggested that, at least in Drosophila, GPCR-reglated pathways might modulate stress resistance....
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...Analysis of the mth gene prouct demonstrated that it belonged to the family of TP binding protein-coupled receptors (GPCR), the amily of seven transmembrane spanning receptors hat modulate a host of signaling pathways....
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3,363 citations
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...EC50 value of succinate on human and mouse GPR91 is 56 and 28 mM, respectively (He et al., 2004)....
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...GPR91 was identified as a succinate receptor in 2004 (He et al., 2004), suggesting that microbially produced succinate may function as a signaling molecule....
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...GPR91 was identified as a succinate receptor in 2004 (He et al., 2004), suggesting that microbially produced succinate may function as a signaling molecule....
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2,487 citations
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..., metabolites may have unanticipated roles as regulatory signals with hormone-like function...
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1,723 citations
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...protein-coupled receptor, suggesting that succinate can also It is frequently hypothesized in the literature that ROS generbe released from cells under some physiological/pathological ation due to SDH mutations may mediate HIF-1 induction circumstances (He et al., 2004)....
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...…to a more infiltrating form. protein-coupled receptor, suggesting that succinate can alsoIt is frequently hypothesized in the literature that ROS generbe released from cells under some physiological/pathologicalation due to SDH mutations may mediate HIF-1 induction circumstances (He et al., 2004)....
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1,225 citations
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...…CHO, Chinese hamster ovary; SCG, superior cervical 2004), but it is now firmly established that it is actually a receptor for -ketoglutarate (He et al., 2004; Qi et al., 2004; Suarez Gonzalez et al., 2004), as was also recently underlined in a report by the Subcommittee (Abbracchio et al.,…...
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..., 2004), but it is now firmly established that it is actually a receptor for α-ketoglutarate (He et al., 2004; Qi et al., 2004; Suarez Gonzalez et al., 2004), as was also recently underlined in a report by the Subcommittee (Abbracchio et al....
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References
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"Citric acid cycle intermediates as ..." refers methods in this paper
...Receptor model The published bovine rhodopsin structure was used as a template for generating a partial GPR91 structure mode...
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