Open AccessJournal Article
Clastogenic effect of cisplatin on Wistar rat bone marrow cells.
M.I. Edelweiss,Trachtenberg A,Pinheiro Ex,da-Silva J,Mariluce Riegel,H.M. Lizardo-Daudt,Mattevi Ms +6 more
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TLDR
The clastogenic effect of the drug cis-diamminedichloroplatinum II (cisplatin, CDDP) was investigated in Wistar rat bone marrow cells and mutagenic effect of CDDP in rats demonstrated for mice bone marrow by micronuclei assay, for murine ovary cells and mice spermatocytes is confirmed.Abstract:
The clastogenic effect of the drug cis-diamminedichloroplatinum II (cisplatin, CDDP) was investigated in Wistar rat bone marrow cells. Male rats, 3 per treatment time, aged 4 months and weighing 250-350 g were injected intraperitoneally with 6.0 mg/kg CDDP solution, and the control group received isotonic saline. The animals were sacrificed 6, 12, 18, 24 and 48 h after the injection. The chromosome preparation was obtained from bone marrow cells. Chromatid and chromosome aberrations were investigated in 300 metaphases per animal. A significant increase in number of chromosome aberrations was observed from 6 to 24 h, the majority being of the break and gap type. After 48 h a progressive reduction was observed, without differences from the negative control. These data confirm the mutagenic effect of CDDP in rats demonstrated for mice bone marrow by micronuclei assay, for murine ovary cells and mice spermatocytes.read more
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Antioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats.
TL;DR: The pretreatment with bixin reduced the total number of chromosome aberrations, inhibited the increase in lipid peroxidation, and inhibited renal glutathione depletion induced by cisplatin, suggesting that bix in may have future clinical application after further studies.
Journal ArticleDOI
Effects of the antioxidants curcumin and vitamin C on cisplatin-induced clastogenesis in Wistar rat bone marrow cells
Lusânia Maria Greggi Antunes,Maria Cristina Picinato Medeiros de Araújo,Joana D'Arc Castania Darin,Maria de Lourdes Pires Bianchi +3 more
TL;DR: Under the present experimental conditions, CMN could prevent cisplatin-induced clastogenesis by acting as a free radical scavenger and the combination between antioxidants would not be effective in protecting against cisplatin-induced chromosomal damage in animals sacrificed 24 h after cisPlatin treatment.
Journal ArticleDOI
The impact of quercetin on cisplatin-induced clastogenesis and apoptosis in murine marrow cells
TL;DR: Overall, this study provides for the first time that quercetin has a protective role in the abatement of cisplatin-induced clastogenesis and apoptosis in the bone marrow cells of mice that resides, at least in part, in its antioxidant effects.
Journal ArticleDOI
Antigenotoxic and anticytotoxic effect of camel milk in mice treated with cisplatin
M. Quita Salwa,A.F. Kurdi Lina +1 more
TL;DR: It is suggested that this milk has some antioxidant effect, and the antigenotoxic mechanism of this milk needs to be explored further before their use during cisplatin chemotherapy.
Journal ArticleDOI
Sensitization of cisplatin therapy by a naphthalimide based organoselenium compound through modulation of antioxidant enzymes and p53 mediated apoptosis.
TL;DR: The results showed that the test compound not only reduced the toxicity of cisplatin but also enhanced its anti-tumor efficacy.
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