Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion
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Cites background from "Clearing the Dead: Apoptotic Cell S..."
...Efferocytosis is mediated by the interaction of apoptotic cell recognition motifs, macrophage receptors, such as MerTK (MER proto-oncogene and tyrosine kinase), and molecules that bridge these 2 components.(117,118) It is possible that the impaired ability of macrophages to efferocytose apoptotic cells in advanced lesions is because of impaired function of these proteins....
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667 citations
Cites background from "Clearing the Dead: Apoptotic Cell S..."
..., 2004); and stress-induced eat-me signals (Hochreiter-Hufford and Ravichandran, 2013), it may be feasible to identify a direct molecular pathway for initiating demyelination in this model....
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References
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Additional excerpts
...3) (Fadok et al. 1992, 1998a, 2001)....
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"Clearing the Dead: Apoptotic Cell S..." refers background in this paper
...For instance, engulfment of uninfected apoptotic cells by tissue resident macrophages is usually immunologically silent; however, engulfment of apoptotic cells via infiltrating macrophages and/or dendritic cells in an inflamed environment has the potential to drive an antigen-specific immune response and break tolerance (Geissmann et al. 2010; Hochreiter-Hufford and Ravichandran 2012)....
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...…usually immunologically silent; however, engulfment of apoptotic cells via infiltrating macrophages and/or dendritic cells in an inflamed environment has the potential to drive an antigen-specific immune response and break tolerance (Geissmann et al. 2010; Hochreiter-Hufford and Ravichandran 2012)....
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"Clearing the Dead: Apoptotic Cell S..." refers background in this paper
...For example, treatment of tumor cells with antracyclins led to cell-surface exposure of calreticulin early during the death program, which was essential for phagocytosis of dying tumor cells by dendritic cells and the initiation of an immune response (Obeid et al. 2007b)....
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...Additionally, calreticulin exposure was linked to immunogenic cell death caused by irradiation and UVC-light treatment (Obeid et al. 2007a)....
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...…and oxidized low-density lipoprotein (LDL)-like moiety (Devitt et al. 1998; Fadok et al. 1998b; Aderem and Underhill 1999; Schlegel et al. 1999), and the exposure of certain intracellular proteins such as calreticulin and annexin I (Arur et al. 2003; Gardai et al. 2005; Obeid et al. 2007a,b)....
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