Journal ArticleDOI
'Click' Chemistry in Polymer and Material Science: An Update
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TLDR
The metal catalyzed azide/alkyne "click" reaction as mentioned in this paper has been widely used in the field of polymer science and is one of the few universal, highly efficient functionalization reactions which combines both high efficiency with an enormously high tolerance of functional groups and solvents.Abstract:
The metal catalyzed azide/alkyne ‘click’ reaction (a variation of the Huisgen 1,3-dipolar cycloaddition reaction between terminal acetylenes and azides) has vastly increased in broadness and application in the field of polymer science. Thus, this reaction represents one of the few universal, highly efficient functionalization reactions, which combines both high efficiency with an enormously high tolerance of functional groups and solvents under highly moderate reaction temperatures (25–70 °C). The present review assembles an update of this reaction in the field of polymer science (linear polymers, surfaces) with a focus on the synthesis of functionalized polymeric architectures and surfaces.read more
Citations
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Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles
R. A. Sperling,Wolfgang J. Parak +1 more
TL;DR: This work aims to review different strategies of surface modification and functionalization of inorganic colloidal nanoparticles with a special focus on the material systems gold and semiconductor nanoparticles, such as CdSe/ZnS.
Journal ArticleDOI
Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials
Rhiannon K. Iha,Karen L. Wooley,Andreas M. Nyström,Daniel J. Burke,Matthew J. Kade,Craig J. Hawker +5 more
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical properties of EMTs and their applications in the treatment of cancer.
Journal ArticleDOI
Thiol-ene “click” reactions and recent applications in polymer and materials synthesis
TL;DR: In this paper, a review highlights examples of recent applications of both the radical-mediated and base/nucleophile-initiated thiol-ene reactions in polymer and materials synthesis.
Journal ArticleDOI
Helical polymers: synthesis, structures, and functions
TL;DR: The chiral stationary phase for high-performance liquid chromatography showed good chiral recognition ability towards various racemates, including polyene and polymethine, which is useful for selective separation of chiral components from polyene-like molecules.
Journal ArticleDOI
Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology.
Kim E. Sapsford,W. Russ Algar,Lorenzo Berti,Kelly Boeneman Gemmill,Brendan J. Casey,Eunkeu Oh,Michael H. Stewart,Igor L. Medintz +7 more
TL;DR: Chemistries that Facilitate Nanotechnology Kim E. Sapsford,† W. Russ Algar, Lorenzo Berti, Kelly Boeneman Gemmill,‡ Brendan J. Casey,† Eunkeu Oh, Michael H. Stewart, and Igor L. Medintz .
References
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Journal ArticleDOI
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
Journal ArticleDOI
Click Chemistry: Diverse Chemical Function from a Few Good Reactions.
TL;DR: In this paper, a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries through heteroatom links (C-X-C), an approach called click chemistry is defined, enabled, and constrained by a handful of nearly perfect "springloaded" reactions.
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Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.
TL;DR: A novel regiospecific copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes to azides on solid-phase is reported, and the X-ray structure of 2-azido-2-methylpropanoic acid has been solved, to yield structural information on the 1, 3-dipoles entering the reaction.
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The growing impact of click chemistry on drug discovery.
TL;DR: The copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes is a particularly powerful linking reaction, due to its high degree of dependability, complete specificity, and the bio-compatibility of the reactants.
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Dendrimers in biomedical applications--reflections on the field.
Sonke Svenson,Donald A. Tomalia +1 more
TL;DR: The reflections on biomedical applications of dendrimers given in this review clearly demonstrate the potential of this new fourth major class of polymer architecture and indeed substantiate the high hopes for the future of dendedrimers.