Clinical Ascertainment of Health Outcomes Among Adults Treated for Childhood Cancer
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5,516 citations
Cites background from "Clinical Ascertainment of Health Ou..."
...However, even many newer, less toxic therapies increase the risk of serious health conditions in long-term childhood cancer survivors.(46) Cognitive impairment, which can vary in severity, affects up to one-third of childhood cancer survivors....
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Cites background from "Clinical Ascertainment of Health Ou..."
...Moreover, clinical studies of cancer survivors treated during childhood suggest that some chemotherapies cause a range of long-term side effects that resemble pathologies associated with aging, including organ dysfunction, cognitive impairment, and secondary neoplasms (8)....
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...Moreover, studies of cancer survivors show that one long-term effect of chemotherapy is the accelerated development of a host of age-associated diseases (8)....
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References
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"Clinical Ascertainment of Health Ou..." refers methods in this paper
...Kaplan-Meier methods were used to estimate the age-specific prevalence of adverse outcomes.(11) SAS version 9....
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769 citations
"Clinical Ascertainment of Health Ou..." refers background in this paper
...4 years) in the Netherlands.(1) Medical assessments were performed according to standardized follow-up protocols; however, specific screening methods and total numbers screened for each condition were not described....
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659 citations
"Clinical Ascertainment of Health Ou..." refers background in this paper
...Prior studies investigating longterm outcomes of adults treated for cancer during childhood have largely relied on survivor self-report of outcomes or registry data.(2-5) Research programs in the United States reporting outcomes based on medical assessments have featured relatively small cohorts, including those with pediatric-aged survivors....
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...CURATIVE THERAPY FOR PEDIatric malignancies has produced a growing population of adults formerly treated for childhood cancer who are at risk for health problems(1-3) that appear to increase with aging.(2-5) The prevalence of cancer-related toxic effects that are systematically ascertained through formal clinical assessments has not been well studied....
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650 citations
"Clinical Ascertainment of Health Ou..." refers background in this paper
...For some organ systems evaluated, the results of risk-based assessment revealed a substantial number of previously undiagnosed problems typically observed in older populations.(17-21) This had a marked effect on the estimates of age-specific organ dysfunction....
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