Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
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TLDR
During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.Citations
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Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Ling Mao,Huijuan Jin,Mengdie Wang,Yu Hu,Shengcai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Xiaoping Miao,Yanan Li,Bo Hu +12 more
TL;DR: During the epidemic period of COVID-19, clinicians should suspect severe acute respiratory syndrome coronavirus 2 infection as a differential diagnosis to avoid delayed diagnosis or misdiagnosis and lose the chance to treat and prevent further transmission.
Journal ArticleDOI
Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases.
Tao Ai,Zhenlu Yang,Hongyan Hou,Chenao Zhan,Chong Chen,Wen-Zhi Lv,Qian Tao,Ziyong Sun,Liming Xia +8 more
TL;DR: Chest CT has a high sensitivity for diagnosis of CO VID-19 and may be considered as a primary tool for the current COVID-19 detection in epidemic areas, as well as for patients with multiple RT-PCR assays.
Journal ArticleDOI
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.
Giacomo Grasselli,Giacomo Grasselli,Alberto Zangrillo,Alberto Zanella,Alberto Zanella,Massimo Antonelli,Massimo Antonelli,Luca Cabrini,Antonio Castelli,Danilo Cereda,Antonio Coluccello,Giuseppe Foti,Roberto Fumagalli,Giorgio Antonio Iotti,Nicola Latronico,Luca Lorini,Stefano Merler,Giuseppe Natalini,Alessandra Piatti,Marco Ranieri,Anna Mara Scandroglio,Enrico Storti,Maurizio Cecconi,Antonio Pesenti,Antonio Pesenti +24 more
TL;DR: Patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy were characterized, including data on clinical management, respiratory failure, and patient mortality.
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Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.
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Incidence of thrombotic complications in critically ill ICU patients with COVID-19.
Frederikus A. Klok,Marieke J. H. A. Kruip,N.J.M. van der Meer,M.S. Arbous,Diederik Gommers,K.M. Kant,F H J Kaptein,J. van Paassen,M A M Stals,Menno V. Huisman,Henrik Endeman +10 more
TL;DR: The findings reinforce the recommendation to strictly apply pharmacological thrombosis prophylaxis in all COVID-19 patients admitted to the ICU, and are strongly suggestive of increasing the prophYLaxis towards high-prophylactic doses, even in the absence of randomized evidence.
References
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Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany.
Camilla Rothe,Mirjam Schunk,Peter Sothmann,Gisela Bretzel,Guenter Froeschl,Claudia Wallrauch,Thorbjörn Zimmer,Verena Thiel,Christian Janke,Wolfgang Guggemos,M Seilmaier,Christian Drosten,Patrick Vollmar,Katrin Zwirglmaier,Sabine Zange,Roman Wölfel,Michael Hoelscher +16 more
TL;DR: Investigators in Germany detected the spread of the novel coronavirus (2019-nCoV) from a person who had recently traveled from China and found it to be a novel virus.
Journal ArticleDOI
Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America
Joshua P. Metlay,Grant W. Waterer,Ann C. Long,Antonio Anzueto,Jan Brozek,Kristina Crothers,Laura A. Cooley,Laura A. Cooley,Nathan C. Dean,Michael J. Fine,Scott A. Flanders,Marie R. Griffin,Mark L. Metersky,Daniel M. Musher,Daniel M. Musher,Marcos I. Restrepo,Marcos I. Restrepo,Cynthia G. Whitney +17 more
TL;DR: Although some recommendations remain unchanged from the 2007 guideline, the availability of results from new therapeutic trials and epidemiological investigations led to revised recommendations for empiric treatment strategies and additional management decisions.
Journal ArticleDOI
Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus
Abdullah M. Assiri,Allison McGeer,Trish M. Perl,Connie S. Price,Abdullah A. Al Rabeeah,Derek A. T. Cummings,Zaki N. Alabdullatif,Maher Assad,Abdulmohsen Almulhim,Hatem Q. Makhdoom,Hossam Madani,Rafat F. Alhakeem,Jaffar A. Al-Tawfiq,Matthew Cotten,Simon J. Watson,Paul Kellam,Paul Kellam,Alimuddin Zumla,Alimuddin Zumla,Ziad A. Memish +19 more
TL;DR: Person-to-person transmission of MERS-CoV can occur in health care settings and may be associated with considerable morbidity and surveillance and infection-control measures are critical to a global public health response.
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Middle East respiratory syndrome.
TL;DR: The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012.
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Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam.
Lan T. Phan,Thuong Vu Nguyen,Quang C Luong,Thinh V. Nguyen,Hieu T. Nguyen,Hung Q. Le,Thuc T. Nguyen,Thang Minh Cao,Quang D Pham +8 more
TL;DR: Human-to-Human Coronavirus Transmission in Vietnam The authors describe transmission of 2019-nCoV from a father, who had flown with his wife from Wuhan to Hanoi, to the son, who met his father and ...
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