Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
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TLDR
Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.About:
This article is published in The Lancet.The article was published on 2020-03-28 and is currently open access. It has received 20189 citations till now. The article focuses on the topics: Cohort study & Retrospective cohort study.read more
Citations
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Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.
Safiya Richardson,Safiya Richardson,Jamie S. Hirsch,Jamie S. Hirsch,Mangala Narasimhan,James M. Crawford,Thomas McGinn,Thomas McGinn,Karina W. Davidson,Karina W. Davidson,Douglas P. Barnaby,Douglas P. Barnaby,Lance B Becker,John Chelico,John Chelico,Stuart L. Cohen,Stuart L. Cohen,Jennifer Cookingham,Kevin Coppa,Michael A Diefenbach,Andrew J. Dominello,Joan Duer-Hefele,Louise Falzon,Jordan Gitlin,Negin Hajizadeh,Negin Hajizadeh,Tiffany G. Harvin,David Hirschwerk,Eun Ji Kim,Eun Ji Kim,Zachary Kozel,Lyndonna Marrast,Lyndonna Marrast,Jazmin N. Mogavero,Gabrielle A. Osorio,Michael Qiu,Theodoros P. Zanos +36 more
TL;DR: This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area and assesses outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death.
Journal ArticleDOI
Endothelial cell infection and endotheliitis in COVID-19.
Zsuzsanna Varga,Andreas J. Flammer,Peter Steiger,Martina Haberecker,Rea Andermatt,Annelies S. Zinkernagel,Mandeep R. Mehra,Reto A. Schuepbach,Frank Ruschitzka,Holger Moch +9 more
TL;DR: The vascular endothelium is an active paracrine, endocrine, and Endothelial cell infection and endotheliitis in COVID-19 and recruitment of immune cells can result in widespread endothelial dysfunction associated with apoptosis.
Journal ArticleDOI
Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
Journal ArticleDOI
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.
Giacomo Grasselli,Giacomo Grasselli,Alberto Zangrillo,Alberto Zanella,Alberto Zanella,Massimo Antonelli,Massimo Antonelli,Luca Cabrini,Antonio Castelli,Danilo Cereda,Antonio Coluccello,Giuseppe Foti,Roberto Fumagalli,Giorgio Antonio Iotti,Nicola Latronico,Luca Lorini,Stefano Merler,Giuseppe Natalini,Alessandra Piatti,Marco Ranieri,Anna Mara Scandroglio,Enrico Storti,Maurizio Cecconi,Antonio Pesenti,Antonio Pesenti +24 more
TL;DR: Patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy were characterized, including data on clinical management, respiratory failure, and patient mortality.
Journal ArticleDOI
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
Bin Cao,Yeming Wang,Danning Wen,Wen Liu,Jingli Wang,Guohui Fan,Lianguo Ruan,Bin Song,Yanping Cai,Ming Wei,Xingwang Li,Jia'an Xia,Nanshan Chen,Jie Xiang,Ting Yu,Tao Bai,Xuelei Xie,Li Zhang,Caihong Li,Ye Yuan,Hua Chen,Huadong Li,Hanping Huang,Shengjing Tu,Fengyun Gong,Ying Liu,Yuan Wei,Chongya Dong,Fei Zhou,Xiaoying Gu,Jiuyang Xu,Zhibo Liu,Yi Zhang,Li Hui,Lianhan Shang,Ke Wang,Kunxia Li,Xia Zhou,Xuan Dong,Zhaohui Qu,Sixia Lu,Xujuan Hu,Shunan Ruan,Shanshan Luo,Jing Wu,Lu Peng,Fang Cheng,Lihong Pan,Jun Zou,Chunmin Jia,Juan Wang,Xia Liu,Shuzhen Wang,Xudong Wu,Qin Ge,Jing He,Haiyan Zhan,Fang Qiu,Li Guo,Chaolin Huang,Thomas Jaki,Frederick G. Hayden,Peter Horby,Dingyu Zhang,Chen Wang +64 more
TL;DR: In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care, and future trials in patients withsevere illness may help to confirm or exclude the possibility of a treatment benefit.
References
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Laboratory-Confirmed Respiratory Infections as Predictors of Hospital Admission for Myocardial Infarction and Stroke: Time-Series Analysis of English Data for 2004-2015.
Ruth Blackburn,Honxin Zhao,Richard Pebody,Andrew Hayward,Charlotte Warren-Gash,Charlotte Warren-Gash +5 more
TL;DR: Investigation of population-level associations between the timing of myocardial infarction or stroke hospital admissions and laboratory-confirmed respiratory infections found infection with human metapneumovirus, respiratory syncytial virus, influenza, rhinov virus, and adenovirus was associated with increased ischemic stroke and MI risk in the elderly.
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COVID-19: Development of a robust mathematical model and simulation package with consideration for ageing population and time delay for control action and resusceptibility
TL;DR: A modified SEIRS model with additional exit conditions in the form of death rates and resusceptibility is presented, where the model aims to reflect better on the current scenario and case data reported, such that the spread of the disease and the efficiency of the control action taken can be better understood.
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Factors Associated With Prolonged Viral Shedding in Patients With Avian Influenza A(H7N9) Virus Infection
Yeming Wang,Yeming Wang,Qiang Guo,Zheng Yan,Daming Zhou,Wei Zhang,Shujun Zhou,Yuping Li,Jing Yuan,Timothy M. Uyeki,Xinghua Shen,Wenjuan Wu,Hui Zhao,Yunfu Wu,Jia Shang,Zhengguang He,Yi Yang,Hongsheng Zhao,Yongqing Hong,Zehua Zhang,Min Wu,Tiemin Wei,Xilong Deng,Yijun Deng,Li-hua Cai,Weihua Lu,Hongmei Shu,Lin Zhang,Hong Luo,Y ing Zhou,Heng Weng,Keyi Song,Li Yao,Mingguang Jiang,Boliang Zhao,Ruibin Chi,Boqi Guo,Lin Fu,Long Yu,Haiyan Min,Pu Chen,Shuifang Chen,Liang Hong,Wei Mao,Xiaoping Huang,Lijun Gu,Hui Li,Hui Li,Chen Wang,Chen Wang,Chen Wang,Bin Cao,Bin Cao +52 more
TL;DR: These findings suggest that NAI treatment should be started as soon as possible in patients with suspected A(H7N9) infection and that use of corticosteroids should be prudent.
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Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network.
Fei Zhou,Yimin Wang,Yingmei Liu,Xuedong Liu,Li Gu,Xiaoju Zhang,Zeng-Hui Pu,Guoru Yang,Bo Liu,Qingrong Nie,Bing Xue,Jing Feng,Qiang Guo,Jian-hua Liu,Hong Fan,Jin Chen,Y. Zhang,Zhenyang Xu,Min Pang,Yu Chen,Xiu-Hong Nie,Zhigang Cai,Jin-Fu Xu,Kun Peng,Xiangxin Li,Pingchao Xiang,Z Y Zhang,Shujuan Jiang,Xin Su,Jie Zhang,Yanming Li,Xiuhong Jin,Rongmeng Jiang,Jian-Ping Dong,Yuanlin Song,Hong Zhou,Chen Wang,Bin Cao +37 more
TL;DR: The high incidence of complications in non- influenza viral pneumonia and similar impact of non-influenza respiratory viruses relative to influenza virus on disease severity and outcomes suggest more attention should be given to CAP caused by non-Influenza virus.
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Cardiovascular complications of acute respiratory infections: current research and future directions.
TL;DR: A large number of patients with known ‘traditional’ risk factors for cardiovascular disease (CVD) such as high blood pressure, high cholesterol, or high triglyceride levels are thought to be at risk for IHD and stroke.
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