Clinical effectiveness of contemporary adhesives: a systematic review of current clinical trials.

doi:10.1016/J.DENTAL.2005.02.003

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Clinical effectiveness of contemporary adhesives: a systematic review of current clinical trials.

Journal Article•DOI•

Clinical effectiveness of contemporary adhesives: a systematic review of current clinical trials.

Marleen Peumans¹, P. Kanumilli¹, J. De Munck¹, K.L. Van Landuyt¹, Paul Lambrechts¹, B. Van Meerbeek¹ - Show less +2 more•Institutions (1)

Catholic University of Leuven¹

01 Sep 2005-Dental Materials (Elsevier)-Vol. 21, Iss: 9, pp 864-881

TL;DR: Comparison of retention of class-V adhesive restorations as a measure to determine clinical bonding effectiveness of adhesives revealed that glass‐ionomers most effectively and durably bond to tooth tissue.

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About: This article is published in Dental Materials.The article was published on 2005-09-01. It has received 744 citations till now.

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Journal Article•DOI•

Systematic review of the chemical composition of contemporary dental adhesives

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Kirsten Van Landuyt¹, Johan Snauwaert², Jan De Munck¹, Marleen Peumans¹, Yasuhiro Yoshida³, André Poitevin¹, Eduardo Coutinho¹, Kazuomi Suzuki³, Paul Lambrechts¹, Bart Van Meerbeek¹ - Show less +6 more•Institutions (3)

Catholic University of Leuven¹, Laboratory of Solid State Physics², Okayama University³

01 Sep 2007-Biomaterials

TL;DR: The aim of this article is to systematically review the ingredients commonly used in current dental adhesives as well as the properties of these ingredients.

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1,218 citations

Cites background from "Clinical effectiveness of contempor..."

...The good in vitro and clinical outcome of Clearfil SE Bond from Kuraray [8,78,79], which is a 2-SEA that contains 10-MDP, may be partly attributed to the intense chemical adhesion with tooth tissue....
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...5-NMSA, a monomer used in former adhesives of Kuraray and in Panavia cements, has a salicyl group that is intended to chelate with calcium in order to obtain a desensitizing effect....
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...An additional mechanism of ionic bonding of acidic monomers and calcium in hydroxyapatite was recently established [7], which may explain the good clinical performance of some of these mild self-etch adhesives [8]....
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...3), a monomer patented by Kuraray, is a compound of the antibacterial agent dodecylpyridinium bromide and a methacryl group [30]....
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...E&R) Adper Scotchbond Multi-Purpose 3M ESPE, St Paul, MN, USA Component 1(etchant): 35% H3PO4 Primer: 3.3 Component 2: (Scotchbond Multi-Purpose primer) HEMA, polyalkenoic acid polymer, water Bonding: 8.2 Component 3: (Scotchbond Multi-Purpose adhesive) Bis-GMA, HEMA, tertiary amines (both for light-cure and self-cure initiators), photo-initiator Adper Scotchbond Multi-Purpose Plus 3M ESPE, St Paul, MN, USA Component 1 (etchant): 35% H3PO4 Comp 1,5: 8,1 Dual cure Component 1,5: (Scotchbond Multi-Purpose Plus activator) ethanol, sulfinic acid salt, sodium salt Comp 2: 3,3 Component 2: (Scotchbond Multi-Purpose primer) HEMA, polyalkenoic adic polymer, water Comp1,5 +comp 2: 4,7 Component 3: (Scotchbond Multi-Purpose adhesive) Bis-GMA, HEMA, tertiary amines (both for light-cure and self-cure initiators), photo-initiator Comp 3: 8,2 Component 3,5: (Scotchbond Multi-Purpose Plus catalyst) Bis-GMA, HEMA, BPO Comp 3,5: 5,7 Comp 3,5+comp 3: 6,9 All-Bond 2 Bisco Inc, Schaumburg, IL, USA Etchant: 10% H3PO4 (All-etch) or 32% H3PO4 (Uni-etch) Primers mixed: 5.7 Dual cure primer Wet Primer A: NTG-GMA, acetone, ethanol, water Bonding: 7.5 Dual cure bonding when mixed with Prebond Primer B: BPDM, photo-initiator, acetone Pre-bond: 7 Bonding: Bis-GMA, UDMA, HEMA Pre-bond+bonding: 7 Pre-Bond: Bis-GMA, TEGDMA, BPO, HEMA Bond-it Pentron Corporation, Wallingford, CT, USA Etchant: 37% H3PO4 Light cure (or dual cure when activator is added) Wet bonding Primer A: NTG-GMA, acetone Primer B: PMGDM, Bis-GMA, HEMA, acetone, photo-initiator Adhesive resin: Bis-GMA, HEMA, UDMA, HDDMA with amine accelerator, photoinitiator, BPO Clearfil Liner Bond Kuraray Medical Inc, Tokyo, Japan Etchant: K-etchant SA primer: 5-NMSA, ethanol, water Photo bond: Catalyst liquid: MDP, HEMA, Bis-GMA, hydrophobic dimethacrylate, BPO, CQ Universal liquid: N,N0-diethanol p-toluidine, sodium benzen sulfinate, ethanol Ecusit-Primer/ Mono DMG, Hamburg, Germany Ecusit-Etch: 37% H3PO4 2.6 Light cure Preferentially moistPrimer: maleic acid, HEMA, polymethacrylated polycarbonic acid Bonding: Bis-GMA, TEGDMA, polymethacrylated oligomaleic acid FL bond (Imperva Fluorobond in Japan) Shofu Inc., Kyoto, Japan Etchant: 7% H3PO4 2.2 Fluoride releasing Dry Primer A: water, acetone, initiator Light cure Primer B: 4-AET, 4-AETA, HEMA, UDMA, TEGDMA, initiator Bond: F-PRG Filler, HEMA, UDMA, TEGDMA, photo-initiator Gluma Solid Bond Gluma Etch: 20–35% H3PO4 1.8 Light cure Wet K.L. Van Landuyt et al. / Biomaterials 28 (2007) 3757–37853760 ARTICLE IN PRESS Table 1 (continued ) Adhesive Manufacturer Composition pH Remarks Dry or wet bonding Heraeus Kulzer, Hanau, Germany Gluma solid bond P: TEGDMA, HEMA, modified polyacrylic acid, maleic acid, acetone, water, photo-initiators, stabilizers Gluma solid bond S: Bis-GMA, TEGDMA, glass filler, SiO2, photo-initiators, stabilizers Optibond Kerr, Orange, CA, USA Etchant: 37.5% H3PO4 Dual cure Primer: HEMA, GPDM, MMEP, water, ethanol, CQ, BHT Dual cure activator (3A): Bis-GMA, HEMA, MMEP, BPO, UV-9, BHT, CQ Dual Cure Paste (3B): Bis-GMA, HEMA, GDMA, DHEPT, ODMAB, filler (fumed SiO2, barium aluminoborosilicate, barium aluminosilicate, Na2SiF6), coupling factor A174 Optibond FL Kerr, Orange, CA, USA Etchant: 37.5% H3PO4 FL Prime: 1.9 Light cure FL Prime: HEMA, GPDM, MMEP, water, ethanol, CQ, BHT Fl Adhesive: 6.9 FL Adhesive: Bis-GMA, HEMA, GDMA, CQ, ODMAB, filler (fumed SiO2, barium aluminoborosilicat, Na2SiF6), coupling factor A174 (approximately 48wt% filled) PAAMA SDI limited, Bayswater, Victoria, Australia Etchant: 37% H3PO4 Primer: 3.5 Wet Primer: acetone, proprietary hydrophilic/ hydrophobic monomer, TEGDMA Bonding: 5 Bonding: UDMA, TEGDMA, stabilizers, CQ Probond DENTSPLY Caulk, Milford, DE, USA Etchant: H3PO4 Wet Primer: PENTA, acetone, ethanol, stabilizers Adhesive: PENTA, UDMA, methacrylate monomers, glutaraldehyde, CQ, stabilizers Quadrant Unibond Cavex Holland B.V., Haarlem, the Netherlands Quadrant total-etch: 20% H3PO4 Light cure Dry Primer: HEMA, TEGDMA, maleic acid, polycarboxylic acid, ethanol, water, CQ Bonding: Bis-GMA, TEGDMA, silicate glass fillers, silica, polycarboxylic acid, CQ Solobond Plus VOCO, Cuxhaven, Germany Etchant: Vococid 35% H3PO4 Primer: 2,4 Wet Primer: water, acetone, hydroxymethacrylate fluorides, acidic monomers, maleic acid Adhesive: 5,8 Adhesive: acetone, BIS-GMA, TEGDMA, hydroxymethacrylate, CQ Syntac Ivoclar Vivadent, Schaan, Liechtenstein Total Etch: 37% H3PO4 Light cure Primer: TEGDMA, PEGDMA, maleic acid, dimethylketon, water Adhesive: PEGDMA, glutaraldehyde, water Two-step etch&rinse adhesive (2-...
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Journal Article•DOI•

State of the art of self-etch adhesives

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B. Van Meerbeek¹, Kumiko Yoshihara¹, Yasuhiro Yoshida², Atsushi Mine², J. De Munck¹, K.L. Van Landuyt¹ - Show less +2 more•Institutions (2)

Catholic University of Leuven¹, Okayama University²

01 Jan 2011-Dental Materials

TL;DR: The major shortcomings of the most simple-to-use one-step (self-etch) adhesives are addressed and special attention is devoted to the AD-concept and the benefit of chemical interfacial interaction with regard to bond durability.

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1,059 citations

Cites background from "Clinical effectiveness of contempor..."

...[1] Peumans M, Kanumilli P, De Munck J, Van Landuyt K, Lambrechts P, Van Meerbeek B....
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...Glass-ionomers have indeed been ecorded with the lowest annual failure rate with regard to lass-V adhesive restorations [1,26]....
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...Finally, inferior clinical performance of one-step adhesives confirmed the less favorable laboratory findings, while it must also be said that the latest generation of one-step adhesives definitely perform better [1,26]....
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Journal Article•DOI•

Longevity of posterior composite restorations: not only a matter of materials

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Flávio Fernando Demarco¹, Marcos Britto Correa¹, Maximiliano Sérgio Cenci¹, Rafael R. Moraes¹, Niek J.M. Opdam² - Show less +1 more•Institutions (2)

Universidade Federal de Pelotas¹, Radboud University Nijmegen Medical Centre²

01 Jan 2012-Dental Materials

TL;DR: A long survival rate for posterior composite restorations can be expected provided that patient, operator and materials factors are taken into account when the restorATIONS are performed.

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762 citations

Journal Article•DOI•

Relationship between bond-strength tests and clinical outcomes

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B. Van Meerbeek¹, Marleen Peumans¹, André Poitevin¹, Atsushi Mine¹, A. Van Ende¹, Aline de Almeida Neves¹, J. De Munck¹ - Show less +3 more•Institutions (1)

Catholic University of Leuven¹

01 Feb 2010-Dental Materials

TL;DR: An extensive literature review with regard to the different laboratory bond-strength test methods and their data provided, along with a second extensive Literature review on clinical effectiveness data of adhesives in terms of retention rates of adhesive Class-V restorations are reported on.

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656 citations

Cites background or methods or result from "Clinical effectiveness of contempor..."

...clinical effectiveness of a restorative treatment [2,6,141,142]....
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...] and clinical Class-V retention rates [2,182]....
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...On the occasion of this manuscript and the ADM 2009 meeting at Portland, the systematic review of the literature that appeared in the period 1998 until 2004 [2], was continued in the same way for the literature that appeared in the period 2004–2009 and has provided new data with regard to annual failure rates per adhesive class [182,183] (Fig....
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...15 – Graph representing the mean annual failure rates per adhesive class, determined according to a systematic review of Class-V clinical trials of adhesives during the period 1998–2004 [2]....
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...Although ecayed/fractured teeth can be reconstructed minimalnvasively and nearly invisibly using adhesive technology, the linical longevity of composite restorations is today still too hort [1,2]....
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Journal Article•DOI•

Limitations in Bonding to Dentin and Experimental Strategies to Prevent Bond Degradation

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Yan Liu¹, Leo Tjäderhane², Lorenzo Breschi³, Annalisa Mazzoni⁴, Nan Li⁵, Jing Mao¹, David H. Pashley, Franklin Chi Meng Tay⁶ - Show less +4 more•Institutions (6)

Huazhong University of Science and Technology¹, Oulu University Hospital², University of Trieste³, University of Bologna⁴, Fujian University of Traditional Chinese Medicine⁵, Georgia Regents University⁶

10 Jan 2011-Journal of Dental Research

TL;DR: Five experimental strategies developed by different research groups for extending the longevity of resin-dentin bonds are examined, finding a combination of several of these strategies should result in overcoming the critical barriers to progress currently encountered in dentin bonding.

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Abstract: The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-colored restorations Bond degradation occurs via hydrolysis of suboptimally polymerized hydrophilic resin components and degradation of water-rich, resin-sparse collagen matrices by matrix metalloproteinases (MMPs) and cysteine cathepsins This review examined data generated over the past three years on five experimental strategies developed by different research groups for extending the longevity of resin-dentin bonds They include: (1) increasing the degree of conversion and esterase resistance of hydrophilic adhesives; (2) the use of broad-spectrum inhibitors of collagenolytic enzymes, including novel inhibitor functional groups grafted to methacrylate resins monomers to produce anti-MMP adhesives; (3) the use of cross-linking agents for silencing the activities of MMP and cathepsins that irreversibly alter the 3-D structures of their catalytic/allosteric domains; (4) ethanol wet-bonding with hydrophobic resins to completely replace water from the extrafibrillar and intrafibrillar collagen compartments and immobilize the collagenolytic enzymes; and (5) biomimetic remineralization of the water-filled collagen matrix using analogs of matrix proteins to progressively replace water with intrafibrillar and extrafibrillar apatites to exclude exogenous collagenolytic enzymes and fossilize endogenous collagenolytic enzymes A combination of several of these strategies should result in overcoming the critical barriers to progress currently encountered in dentin bonding

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560 citations

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References

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Journal Article•

Buonocore memorial lecture, adhesion to enamel and dentin: current status and future challenges

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Bart Van Meerbeek¹, Jan De Munck, Yasuhiro Yoshida, Satoshi Inoue, Marcos A. Vargas, Padmini Vijay, Kirsten Van Landuyt, Paul Lambrechts, Guido Vanherle - Show less +5 more•Institutions (1)

Katholieke Universiteit Leuven¹

01 May 2003-Operative Dentistry

TL;DR: The basic bonding mechanism to enamel and dentin of these three approaches is demonstrated by means of ultramorphological and chemical characterization of tooth-biomaterial interfacial interactions and confirms that conventional three-step etch&rinse adhesives still perform most favorably and are most reliable in the long-term.

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Abstract: Bonding to tooth tissue can be achieved through an "etch&rinse," "self-etch" or "glass-ionomer" approach. In this paper, the basic bonding mechanism to enamel and dentin of these three approaches is demonstrated by means of ultramorphological and chemical characterization of tooth-biomaterial interfacial interactions. Furthermore, bond-strength testing and measurement of marginal-sealing effectiveness (the two most commonly employed methodologies to determine "bonding effectiveness" in the laboratory) are evaluated upon their value and relevance in predicting clinical performance. A new dynamic methodology to test biomaterial-tooth bonds in a fatigue mode is introduced with a recently developed micro-rotary fatigue-testing device. Eventually, today's adhesives will be critically weighted upon their performance in diverse laboratory studies and clinical trials. Special attention has been given to the benefits/drawbacks of an etch&rinse versus a self-etch approach and the long-term performance of these adhesives. Correlating data gathered in the laboratory with clinical results clearly showed that laboratory research CAN predict clinical effectiveness. Although there is a tendency to simplify bonding procedures, the data presented confirm that conventional three-step etch&rinse adhesives still perform most favorably and are most reliable in the long-term. Nevertheless, a self-etch approach may have the best future perspective. Clinically, when adhesives no longer require an "etch&rinse" step, the application time, and probably more importantly, the technique-sensitivity are substantially reduced. Especially "mild," two-step self-etch adhesives that bond through a combined micromechanical and chemical interaction with tooth tissue closely approach conventional three-step systems in bonding performance.

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1,721 citations

"Clinical effectiveness of contempor..." refers background in this paper

...This superior performance in laboratory and clinical research must probably to a great extent be attributed to optimal enamel interlocking and dentin hybridization, as was demonstrated in several ultra-morphologic interface analyses [1,9,35,36]....
[...]
...This selfadhesiveness must be ascribed to combined micromechanical interlocking and chemical interaction [9,10]....
[...]
...Based upon the underlying adhesion strategy, three mechanisms of adhesion are currently in use with modern adhesives [8,9]....
[...]
...Despite the excellent clinical performance of the glass–ionomer adhesive, glass–ionomers commonly give lower scores than resin-based adhesives in bond strength tests [8,9, 28]....
[...]
...Furthermore, within the shallow hybrid layer residual hydroxyapatite around the exposed collagen fibrils remains available for additional chemical interaction with the functional monomers [9,10]....
[...]

Journal Article•DOI•

Setting Stress in Composite Resin in Relation to Configuration of the Restoration

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Albert J. Feilzer¹, A.J. de Gee¹, Carel L. Davidson¹•Institutions (1)

University of Amsterdam¹

01 Nov 1987-Journal of Dental Research

TL;DR: It was shown that in most of the clinically relevant cavity configurations, the stress-relieving flow is not sufficient to preserve adhesion to dentin by dentin-bonding agents.

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Abstract: The setting stress in composite resins was studied as a function of restoration shape. The shape is described by the configuration factor, C, the ratio of the restoration's bonded to unbonded (free) surfaces. In an experimental set-up, the shape of the restoration was simulated by cylindrical forms of various dimensions. The shrinkage stress was measured continuously. It was shown that in most of the clinically relevant cavity configurations, the stress-relieving flow is not sufficient to preserve adhesion to dentin by dentin-bonding agents.

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1,095 citations

Journal Article•DOI•

Comparative Study on Adhesive Performance of Functional Monomers

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Yasuhiro Yoshida¹, K. Nagakane, R. Fukuda, Y. Nakayama, Masayuki Okazaki, Hideaki Shintani, Satoshi Inoue, Yoh-ichi Tagawa, Kazuomi Suzuki, J. De Munck, B. Van Meerbeek - Show less +7 more•Institutions (1)

Okayama University¹

01 Jun 2004-Journal of Dental Research

TL;DR: Besides self-etching dentin, specific functional monomers have additional chemical bonding efficacy that is expected to contribute to their adhesive potential to tooth tissue.

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Abstract: Mild self-etch adhesives demineralize dentin only partially, leaving hydroxyapatite around collagen within a submicron hybrid layer. We hypothesized that this residual hydroxyapatite may serve as a receptor for chemical interaction with the functional monomer and, subsequently, contribute to adhesive performance in addition to micro-mechanical hybridization. We therefore chemically characterized the adhesive interaction of 3 functional monomers with synthetic hydroxyapatite, using x-ray photoelectron spectroscopy and atomic absorption spectrophotometry. We further characterized their interaction with dentin ultra-morphologically, using transmission electron microscopy. The monomer 10-methacryloxydecyl dihydrogen phosphate (10-MDP) readily adhered to hydroxyapatite. This bond appeared very stable, as confirmed by the low dissolution rate of its calcium salt in water. The bonding potential of 4-methacryloxyethyl trimellitic acid (4-MET) was substantially lower. The monomer 2-methacryloxyethyl phenyl hydrogen phosphate (phenyl-P) and its bond to hydroxyapatite did not appear to be hydrolytically stable. Besides self-etching dentin, specific functional monomers have additional chemical bonding efficacy that is expected to contribute to their adhesive potential to tooth tissue.

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1,035 citations

"Clinical effectiveness of contempor..." refers background in this paper

...Adhesion is consequently obtained micro-mechanically through shallow hybridization and by additional chemical interaction of specific carboxyl/phosphate groups of functional monomers with residual hydroxyapatite [10]....
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...This selfadhesiveness must be ascribed to combined micromechanical interlocking and chemical interaction [9,10]....
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...Furthermore, within the shallow hybrid layer residual hydroxyapatite around the exposed collagen fibrils remains available for additional chemical interaction with the functional monomers [9,10]....
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Journal Article•DOI•

Aggressiveness of contemporary self-etching systems. I: Depth of penetration beyond dentin smear layers.

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Franklin Chi Meng Tay¹, David H. Pashley²•Institutions (2)

University of Hong Kong¹, Georgia Regents University²

01 Jul 2001-Dental Materials

TL;DR: In this article, the authors examined the aggressiveness of three self-etching adhesive systems in penetrating dentin smear layers of different thickness using transmission electron microscopy (TEM).

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693 citations

Journal Article•DOI•

Four-year Water Degradation of Total-etch Adhesives Bonded to Dentin

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J. De Munck¹, B. Van Meerbeek, Yasuhiro Yoshida, Satoshi Inoue, Marcos A. Vargas, Kazuomi Suzuki, Paul Lambrechts, G. Vanherle - Show less +4 more•Institutions (1)

Catholic University of Leuven¹

01 Feb 2003-Journal of Dental Research

TL;DR: It is concluded that resin bonded to enamel protected the resin-dentin bond against degradation, while direct exposure to water for 4 years affected bonds produced by two-step total-etch adhesives.

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Abstract: Resin-dentin bonds degrade over time. The objective of this study was to evaluate the influence of variables like hybridization effectiveness and diffusion/elution of interface components on degradation. Hypotheses tested were: (1) There is no difference in degradation over time between two- and three-step total-etch adhesives; and (2) a composite-enamel bond protects the adjacent composite-dentin bond against degradation. The micro-tensile bond strength (microTBS) to dentin of 2 three-step total-etch adhesives was compared with that of 2 two-step total-etch adhesives after 4 years of storage in water. Quantitative and qualitative failure analyses were conducted correlating Fe-SEM and TEM. Indirect exposure to water did not significantly reduce the microTBS of any adhesive, while direct exposure resulted in a significantly reduced microTBS of both two-step adhesives. It is concluded that resin bonded to enamel protected the resin-dentin bond against degradation, while direct exposure to water for 4 years affected bonds produced by two-step total-etch adhesives.

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611 citations

"Clinical effectiveness of contempor..." refers background in this paper

...In vitro studies also revealed that two-step etch-and-rinse adhesives bond less effectively/durably because of their reduced infiltration/hybridization potential [23]....
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...It has been hypothesized that this reduced durability is related to the incorporation of a high molecular-weight polyalkenoic-acid copolymer (also present in Scotchbond 1 and Prompt L-Pop) [23]....
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...three-step adhesives commonly perform well in laboratory tests [22–26], simplified adhesives do not, and are less reliable and predictive....
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...Acompromisedbondingeffectiveness in the long-termwasalsonoticed invitro for Scotchbond Multi-Purpose [22,23,25,42,43]....
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...This durable clinical effectiveness confirms laboratory research, in which three-step etch-and-rinse adhesives are considered as the ‘gold standard’ to compare the performance of new-generation adhesives with [23]....
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