Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review
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...In addition, HCQ treatment may reduce the risk of clotting events in SLE [17–20]....
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...This opinion was based on a prospective controlled trial [17] showing flare rates of lupus are lower in SLE patients receiving HCQ compared to those in whom HCQ was replaced with a placebo, and on recent cross-sectional and prospective data [18, 19] showing significantly lower damage accrual, including renal damage, in SLE patients receiving HCQ compared to those without HCQ....
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...K There is low-quality evidence that hydroxychloroquine may protect against the onset of LN, against relapses of LN, ESRD, vascular thrombosis, and that it has a favorable impact on lipid profiles.(674)...
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"Clinical efficacy and side effects ..." refers background in this paper
...As a consequence, more than 50% of patients in many SLE cohorts have never been treated with AMs....
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