Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
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Cites background from "Clinical management of salivary gla..."
..., decreased buffer capacity, pH, immunoglobulin concentrations, defensins), and dietary changes may increase the risk for mucosal infections and rapidly progressing dental demineralization and caries [57]....
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160 citations
Cites background from "Clinical management of salivary gla..."
...The major cause of dry mouth is a dramatic loss of the secretory acinar cells (Hall, 2000; Vissink et al., 2010), which is irreversible and for which no cure currently exists....
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...Estimates of acinar cell turnover range from 50 to 125 days in salivary glands (Vissink et al., 2010; Zajicek et al., 1985) and acinar cell replacement is expected to occur within the 6-month chase period....
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...The sensitivity of salivary glands to radiation has been considered an anomaly, because acinar cells are thought to be post-mitotic (Vissink et al., 2010)....
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155 citations
Cites background from "Clinical management of salivary gla..."
...Int J Radiat Oncol Biol Phys 78(4):983–991....
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...As a result, these patients suffer considerable morbidity, including oral infections (Candidiasis, rampant caries), mucositis, dysphagia, and frank discomfort, with a marked decline in quality of life (4, 6)....
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References
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"Clinical management of salivary gla..." refers methods in this paper
...These include ways to: (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy....
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