Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C19 and Voriconazole Therapy.
Brad Moriyama,A. Owusu Obeng,A. Owusu Obeng,Julia M. Barbarino,Scott R. Penzak,Stacey A. Henning,Stuart A. Scott,José A. G. Agúndez,John R. Wingard,Howard L. McLeod,Teri E. Klein,Shane J Cross,Kelly E. Caudle,Thomas J. Walsh +13 more
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TLDR
Evidence from the literature supporting this association is summarized and therapeutic recommendations for the use of voriconazole for treatment based on CYP2C19 genotype are provided.Abstract:
Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum concentrations, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 ultrarapid metabolizers have decreased trough voriconazole concentrations, delaying achievement of target blood concentrations; whereas poor metabolizers have increased trough concentrations and are at increased risk of adverse drug events. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of voriconazole for treatment based on CYP2C19 genotype (updates at https://cpicpgx.org/guidelines/ and www.pharmgkb.org).read more
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Journal ArticleDOI
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.
Kelly E. Caudle,Katrin Sangkuhl,Michelle Whirl-Carrillo,Jesse J. Swen,Cyrine E. Haidar,Teri E. Klein,Roseann S. Gammal,Roseann S. Gammal,Mary V. Relling,Stuart A. Scott,Stuart A. Scott,Daniel L. Hertz,Henk-Jan Guchelaar,Andrea Gaedigk,Andrea Gaedigk +14 more
TL;DR: Broad adoption of the proposed CYP2D6 genotype to phenotype translation method by guideline developers, and clinical laboratories as well as researchers will result in more consistent interpretation of CYP1D7 genotype, leading to inconsistent therapeutic recommendations and confusion among patients and clinicians.
Journal ArticleDOI
Comparison of the Guidelines of the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working Group.
Paul Cd Bank,Kelly E. Caudle,Jesse J. Swen,Roseann S. Gammal,Michelle Whirl-Carrillo,Teri E. Klein,M. V. Relling,Henk-Jan Guchelaar +7 more
TL;DR: The aim of this paper is to compare both initiatives and explore differences between the published guidelines, with the objective to achieve harmonization.
Journal ArticleDOI
PharmVar GeneFocus: CYP2D6.
Zeruesenay Desta,Ahmed El-Boraie,Li Gong,Andrew A. Somogyi,Volker M. Lauschke,Collet Dandara,Kathrin Klein,Kathrin Klein,Neil A. Miller,Neil A. Miller,Teri E. Klein,Rachel F. Tyndale,Michelle Whirl-Carrillo,Andrea Gaedigk,Andrea Gaedigk +14 more
TL;DR: This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).
Journal ArticleDOI
The Clinical Pharmacogenetics Implementation Consortium: 10 Years Later
Mary V. Relling,Teri E. Klein,Roseann S. Gammal,Roseann S. Gammal,Michelle Whirl-Carrillo,James M. Hoffman,Kelly E. Caudle +6 more
TL;DR: Since its inception, CPIC's interactions with other resources, databases, websites, and genomic communities have grown and the progress of CPIC over the past 10 years is highlighted.
Journal ArticleDOI
Recommendations for Clinical CYP2C19 Genotyping Allele Selection: A Report of the Association for Molecular Pathology.
Victoria M. Pratt,Andria L. Del Tredici,Houda Hachad,Yuan Ji,Lisa V. Kalman,Stuart A. Scott,Stuart A. Scott,Karen E. Weck +7 more
TL;DR: In this article, the Association for Molecular Pathology (PGx) working group developed a set of recommendations for PGx genotyping assays, including a minimum panel of variant alleles and an extended panel of variants.
References
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TL;DR: IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.
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Michelle Whirl-Carrillo,Ellen M. McDonagh,Joan M. Hebert,Li Gong,Katrin Sangkuhl,Caroline F. Thorn,Russ B. Altman,Teri E. Klein +7 more
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TL;DR: IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.
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