Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report.
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Cites background from "Clinical remission of a critically ..."
...Moreover, much of the pathogenesis information regards to SARS-CoV-2 is not fully known....
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...Coronaviruses (CoV) are a large family of viruses that some of them are more known such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV), but some of them are not more known like Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)....
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...SARS-CoV-2 is enveloped, positive-sense, single-stranded RNA virus (with nucleocapsid) by 79.6% sequence identity the same to SARS-CoV [6] that that known as the largest discovered RNA viruses by approximately 30 kb in length genome structure....
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...The genome sequence of SARS-CoV-2 has been submitted to GISAID (https://www.gisaid.org/; accession number: EPI_ISL_402124)....
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...However, there are reports that demonstrate the SARS-CoV-2 virus originated from bats and then moving into camels, but its exact dynamics are currently unknown....
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Cites background from "Clinical remission of a critically ..."
...US regulatory agencies should minimize the regulatory burden so that properly informed, critically ill COVID-19 patients/proxies will have access to expanded UC-MSC therapy (3,96-98)....
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...The studies include a case report (97), one published preliminary report with 7 patients in the treatment group and 3 in the control group with a 14-day follow-up (3), other studies registered to be performed, with information being obtained from submitted protocols....
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...The first coronavirus case treated with umbilical cord cells was reported from China (97) leading to further to speculation and further investigations....
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...Outside of supportive therapies, of all the treatment modalities linked to COVID-19, expanded umbilical cord mesenchymal stem cells (UC-MSCs) may be the closest to being utilized (3,96-104)....
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...The news of reports of stem cell therapy in China with publication of the details of a case of a critically ill 65-year old Chinese woman infected with COVID-19, whose conditions improved after the infusion of MSCs (96,97)....
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"Clinical remission of a critically ..." refers background in this paper
...Persistence of cytokine storm will thus cause the severe organ injury and death [4]....
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2,636 citations
"Clinical remission of a critically ..." refers background in this paper
...Mesenchymal stem cells (MSCs) have been widely used to treat type 2 diabetes, autoimmune disease, spinal cord injury, GVHD, and other diseases with very good safety [7, 8]....
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765 citations