Clinical risk factors for primary graft dysfunction after lung transplantation
Joshua M. Diamond,James C. Lee,Steven M. Kawut,Rupal J. Shah,A. Russell Localio,Scarlett L. Bellamy,David J. Lederer,Edward Cantu,Benjamin A. Kohl,Vibha N. Lama,Sangeeta Bhorade,Maria Crespo,Ejigayehu Demissie,Joshua R. Sonett,Keith M. Wille,Jonathan B. Orens,Ashish S. Shah,Ann Weinacker,Selim M. Arcasoy,Pali D. Shah,David S. Wilkes,Lorraine B. Ware,Scott M. Palmer,Jason D. Christie +23 more
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TLDR
In this paper, a 10-center prospective cohort study was performed to identify donor, recipient, and perioperative risk factors for primary graft dysfunction (PGD) in lung transplant patients.Abstract:
Rationale: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors.Objectives: We sought to identify donor, recipient, and perioperative risk factors for PGD.Methods: We performed a 10-center prospective cohort study enrolled between March 2002 and December 2010 (the Lung Transplant Outcomes Group). The primary outcome was International Society for Heart and Lung Transplantation grade 3 PGD at 48 or 72 hours post-transplant. The association of potential risk factors with PGD was analyzed using multivariable conditional logistic regression.Measurements and Main Results: A total of 1,255 patients from 10 centers were enrolled; 211 subjects (16.8%) developed grade 3 PGD. In multivariable models, independent risk factors for PGD were any history of donor smoking (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.2–2.6; P = 0.002); FiO2 during allograft reperfusion (OR, 1.1 per 10% ...read more
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Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part I: Definition and Grading A 2016 consensus group statement of The International Society for Heart and Lung Transplantation
Gregory I Snell,Roger D. Yusen,David Weill,Martin Strueber,Edward R. Garrity,Anna Reed,A. Pelaez,Timothy P.M. Whelan,Michael Perch,Remzi Bag,Marie Budev,Paul A. Corris,Maria M. Crespo,Chad A. Witt,Edward Cantu,Jason D. Christie +15 more
Journal ArticleDOI
Pathogenesis of Acute Respiratory Distress Syndrome
TL;DR: The goal of this review is to describe the current understanding of the pathogenesis and pathophysiology of ARDS, and explain how clinical trials and preclinical studies of novel therapeutic agents have further refined this understanding.
Journal ArticleDOI
Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients
Gregor Warnecke,J. Moradiellos,Igor Tudorache,Christian Kühn,Murat Avsar,Bettina Wiegmann,Wiebke Sommer,Fabio Ius,Claudia Kunze,Jens Gottlieb,Andrés Varela,Axel Haverich +11 more
TL;DR: Lungs can be safely preserved with the OCS Lung, resulting in complete organ use and successful transplantation in the authors' series of high-risk recipients, and with standard cold storage.
Journal ArticleDOI
Outcomes of intraoperative extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation
Tiago N. Machuca,Stéphane Collaud,Olaf Mercier,Maureen Cheung,Valerie Cunningham,S. Joseph Kim,Sassan Azad,Lianne G. Singer,Kazuhiro Yasufuku,Marc de Perrot,Andrew Pierre,Karen McRae,Thomas K. Waddell,Shaf Keshavjee,Marcelo Cypel +14 more
TL;DR: Early outcomes, such as mechanical ventilation requirement, length of intensive care unit stay, and length of hospital stay, significantly favored extracorporeal membrane oxygenation, and it may be considered as the first choice of intraoperative cardiorespiratory support for lung transplantation.
Journal ArticleDOI
Lung transplantation on cardiopulmonary support: Venoarterial extracorporeal membrane oxygenation outperformed cardiopulmonary bypass
Fabio Ius,Christian Kuehn,Igor Tudorache,Wiebke Sommer,Murat Avsar,Dietmar Boethig,Thomas Fuehner,Jens Gottlieb,Marius M. Hoeper,Axel Haverich,Gregor Warnecke +10 more
TL;DR: Intraoperative ECMO allows for better periprocedural management and reduced postoperative complications and confers a survival benefit compared with CPB, mainly because of lower in-hospital mortality.
References
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Shiraz A. Daud,Roger D. Yusen,Bryan F. Meyers,Murali M. Chakinala,Michael J. Walter,Aviva Aloush,G. Alexander Patterson,Elbert P. Trulock,Ramsey R. Hachem +8 more
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